Effect of himatanthus sucuuba in maternal reproductive outcome and fetal anomaly frequency in rats

dc.contributor.authorSoares, Thaigra de Souza
dc.contributor.authorDamasceno, Débora Cristina [UNESP]
dc.contributor.authorKempinas, Wilma de Grava [UNESP]
dc.contributor.authorResende, Flávia Mayara Campos
dc.contributor.authorSantos, Maria Aparecida Correa dos
dc.contributor.authorHiruma-Lima, Clélia Akiko [UNESP]
dc.contributor.authorVolpato, Gustavo Tadeu
dc.contributor.institutionUniversidade Federal de Mato Grosso (UFMT)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInstituto Estadual de Pesquisa do Amapá (IEPA)
dc.date.accessioned2015-12-07T15:31:37Z
dc.date.available2015-12-07T15:31:37Z
dc.date.issued2015
dc.description.abstractThe aim of this study was to evaluate the effect of Himatanthus sucuuba on the maternal reproductive outcome and fetal anomaly incidence in rats. Pregnant rats were randomly divided into three experimental groups as follows: Control = treated with water (vehicle), treated 250 = treated with H. sucuuba at dose 250 mg/kg, and treated 500 = treated with H. sucuuba at dose 500 mg/kg. The rats were orally treated, by gavage, with H. sucuuba or vehicle (water) during preimplantation and organogenic period (from gestational day 0-14). At day 21 of pregnancy, all rats were killed to obtain maternal-fetal data. The treatment with H. sucuuba at dose of 250 mg/kg caused reduction in placental efficiency and an increase preimplantation loss rate and placenta weight compared with the control. The treated 500 group presented a significant decrease in maternal weight gain, maternal weight gain minus gravid uterus weight, fetal weight, and placental efficiency compared with the control. In this group, there was a decrease in body weight at day 20 of pregnancy and metacarpus ossification and an increase in the preimplantation loss rate and skeletal anomalies compared with other groups. Himatanthus sucuuba extract caused intrauterine growth restriction, preimplantation loss, and developmental delay in the high doses tested.en
dc.description.affiliationLaboratory of System Physiology and Reproductive Toxicology, Institute of Biological and Health Sciences, Universidade Federal de Mato Grosso (UFMT), Barra do Garças, MT, Brasil
dc.description.affiliationLaboratório de Pesquisa Experimental em Ginecologia e Obstetrícia (LAPGO), Departamento de Ginecologia e Obstetrícia, Faculdade de Medicina de Botucatu (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, Brasil
dc.description.affiliationDepartamento de Morfologia, Instituto de Biociências de Botucatu (IBB), Universidade Estadual Paulista (UNESP), Botucatu, SP, Brasil
dc.description.affiliationInstituto Estadual de Pesquisa do Amapá (IEPA), Macapá, AP, Brasil
dc.description.affiliationDepartamento de Fisiologia, Instituto de Biociências de Botucatu (IBB), Universidade Estadual Paulista (UNESP), Botucatu, SP, Brasil
dc.description.affiliationUnespLaboratório de Pesquisa Experimental em Ginecologia e Obstetrícia (LAPGO), Departamento de Ginecologia e Obstetrícia, Faculdade de Medicina de Botucatu (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, Brasil
dc.description.affiliationUnespDepartamento de Morfologia, Instituto de Biociências de Botucatu (IBB), Universidade Estadual Paulista (UNESP), Botucatu, SP, Brasil
dc.description.affiliationUnespDepartamento de Fisiologia, Instituto de Biociências de Botucatu (IBB), Universidade Estadual Paulista (UNESP), Botucatu, SP, Brasil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Mato Grosso (FAPEMAT)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPEMAT: 2009/453362
dc.format.extent190-195
dc.identifierhttp://dx.doi.org/10.1002/bdrb.21152
dc.identifier.citationBirth Defects Research (Part B), Developmental and Reproductive Toxicology, v. 104, n. 5, p. 190-195, 2015.
dc.identifier.doi10.1002/bdrb.21152
dc.identifier.issn1542-9741
dc.identifier.lattes6326450271169741
dc.identifier.lattes3814504901386844
dc.identifier.orcid0000-0002-8645-3777
dc.identifier.pubmed26339763
dc.identifier.urihttp://hdl.handle.net/11449/131104
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofBirth Defects Research (Part B), Developmental and Reproductive Toxicology
dc.relation.ispartofsjr0,515
dc.rights.accessRightsAcesso restrito
dc.sourcePubMed
dc.subjectHimatanthus sucuubaen
dc.subjectMalformationen
dc.subjectPregnancyen
dc.subjectRatsen
dc.subjectReproductive outcomeen
dc.titleEffect of himatanthus sucuuba in maternal reproductive outcome and fetal anomaly frequency in ratsen
dc.typeArtigo
dcterms.rightsHolderWiley-Blackwell
unesp.author.lattes6326450271169741
unesp.author.lattes3814504901386844[6]
unesp.author.orcid0000-0002-8645-3777[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

Arquivos