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Somatic evolution and global expansion of an ancient transmissible cancer lineage

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dc.contributor.authorBaez-Ortega, Adrian
dc.contributor.authorGori, Kevin
dc.contributor.authorStrakova, Andrea
dc.contributor.authorAllen, Janice L.
dc.contributor.authorAllum, Karen M.
dc.contributor.authorBansse-Issa, Leontine
dc.contributor.authorBhutia, Thinlay N.
dc.contributor.authorBisson, Jocelyn L.
dc.contributor.authorBriceño, Cristóbal
dc.contributor.authorDomracheva, Artemio Castillo
dc.contributor.authorCorrigan, Anne M.
dc.contributor.authorCran, Hugh R.
dc.contributor.authorCrawford, Jane T.
dc.contributor.authorDavis, Eric
dc.contributor.authorDe Castro, Karina F.
dc.contributor.authorDe Nardi, Andrigo B. [UNESP]
dc.contributor.authorDe Vos, Anna P.
dc.contributor.authorKeenan, Laura Delgadillo
dc.contributor.authorDonelan, Edward M.
dc.contributor.authorEspinoza Huerta, Adela R.
dc.contributor.authorFaramade, Ibikunle A.
dc.contributor.authorFazil, Mohammed
dc.contributor.authorFotopoulou, Eleni
dc.contributor.authorFruean, Skye N.
dc.contributor.authorGallardo-Arrieta, Fanny
dc.contributor.authorGlebova, Olga
dc.contributor.authorGouletsou, Pagona G.
dc.contributor.authorHäfelin Manrique, Rodrigo F.
dc.contributor.authorHenriques, Joaquim J.G.P.
dc.contributor.authorHorta, Rodrigo S.
dc.contributor.authorIgnatenko, Natalia
dc.contributor.authorKane, Yaghouba
dc.contributor.authorKing, Cathy
dc.contributor.authorKoenig, Debbie
dc.contributor.authorKrupa, Ada
dc.contributor.authorKruzeniski, Steven J.
dc.contributor.authorKwon, Young-Mi
dc.contributor.authorLanza-Perea, Marta
dc.contributor.authorLazyan, Mihran
dc.contributor.authorLopez Quintana, Adriana M.
dc.contributor.authorLosfelt, Thibault
dc.contributor.authorMarino, Gabriele
dc.contributor.authorCastañeda, Simón Martínez
dc.contributor.authorMartínez-López, Mayra F.
dc.contributor.authorMeyer, Michael
dc.contributor.authorMigneco, Edward J.
dc.contributor.authorNakanwagi, Berna
dc.contributor.authorNeal, Karter B.
dc.contributor.authorNeunzig, Winifred
dc.contributor.authorLeathlobhair, Máire Ní
dc.contributor.authorNixon, Sally J.
dc.contributor.authorOrtega-Pacheco, Antonio
dc.contributor.authorPedraza-Ordoñez, Francisco
dc.contributor.authorPeleteiro, Maria C.
dc.contributor.authorPolak, Katherine
dc.contributor.authorPye, Ruth J.
dc.contributor.authorReece, John F.
dc.contributor.authorGutierrez, Jose Rojas
dc.contributor.authorSadia, Haleema
dc.contributor.authorSchmeling, Sheila K.
dc.contributor.authorShamanova, Olga
dc.contributor.authorSherlock, Alan G.
dc.contributor.authorStammnitz, Maximilian
dc.contributor.authorSteenland-Smit, Audrey E.
dc.contributor.authorSvitich, Alla
dc.contributor.authorTapia Martínez, Lester J.
dc.contributor.authorNgoka, Ismail Thoya
dc.contributor.authorTorres, Cristian G.
dc.contributor.authorTudor, Elizabeth M.
dc.contributor.authorVan Der Wel, Mirjam G.
dc.contributor.authorViţălaru, Bogdan A.
dc.contributor.authorVural, Sevil A.
dc.contributor.authorWalkinton, Oliver
dc.contributor.authorWang, Jinhong
dc.contributor.authorWehrle-Martinez, Alvaro S.
dc.contributor.authorWiddowson, Sophie A.E.
dc.contributor.authorStratton, Michael R.
dc.contributor.authorAlexandrov, Ludmil B.
dc.contributor.authorMartincorena, Iñigo
dc.contributor.authorMurchison, Elizabeth P.
dc.contributor.institutionUniversity of Cambridge
dc.contributor.institutionAnimal Management in Rural and Remote Indigenous Communities (AMRRIC)
dc.contributor.institutionWorld Vets
dc.contributor.institutionStichting Dierenbescherming Suriname
dc.contributor.institutionGovernment of Sikkim
dc.contributor.institutionEaster Bush Campus
dc.contributor.institutionUniversity of Chile
dc.contributor.institutionUniversity of Panamá
dc.contributor.institutionSt. George's University
dc.contributor.institutionNakuru District Veterinary Scheme Ltd
dc.contributor.institutionAnimal Medical Centre
dc.contributor.institutionUC Davis School of Veterinary Medicine
dc.contributor.institutionCentro Universitário de Rio Preto (UNIRP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionLadybrand Animal Clinic
dc.contributor.institutionVeterinary Clinic Sr. Dog's
dc.contributor.institutionWorld Vets Latin America Veterinary Training Center
dc.contributor.institutionNational Veterinary Research Institute
dc.contributor.institutionAnimal Clinic
dc.contributor.institutionIntermunicipal Stray Animals Care Centre (DIKEPAZ)
dc.contributor.institutionAnimal Protection Society of Samoa
dc.contributor.institutionUniversity of Zulia
dc.contributor.institutionVeterinary Clinic BIOCONTROL
dc.contributor.institutionUniversity of Thessaly
dc.contributor.institutionHospital Veterinário Berna
dc.contributor.institutionUniversidade Vila Velha
dc.contributor.institutionVeterinary Clinic Zoovetservis
dc.contributor.institutionÉcole Inter-états des Sciences et Médecine Vétérinaires de Dakar
dc.contributor.institutionUtrecht University
dc.contributor.institutionVetexpert Veterinary Group
dc.contributor.institutionVeterinary Clinic Lopez Quintana
dc.contributor.institutionSaint Gilles les Bains
dc.contributor.institutionUniversity of Messina
dc.contributor.institutionUniversidad Autónoma del Estado de México
dc.contributor.institutionUniversidad de las Américas
dc.contributor.institutionChampalimaud Center for the Unknown
dc.contributor.institutionTouray and Meyer Vet Clinic
dc.contributor.institutionHillside Animal Hospital
dc.contributor.institutionKampala Veterinary Surgery
dc.contributor.institutionAsavet Veterinary Charities
dc.contributor.institutionVets Beyond Borders
dc.contributor.institutionAutonomous University of Yucatan
dc.contributor.institutionUniversidad de Caldas
dc.contributor.institutionUniversity of Lisbon
dc.contributor.institutionFour Paws International
dc.contributor.institutionHelp in Suffering
dc.contributor.institutionVeterinary Clinic Dr José Rojas
dc.contributor.institutionEngineering and Management Sciences
dc.contributor.institutionCorozal Veterinary Clinic
dc.contributor.institutionVeterinary Clinic Vetmaster
dc.contributor.institutionState Hospital of Veterinary Medicine
dc.contributor.institutionJomo Kenyatta University of Agriculture and Technology
dc.contributor.institutionUniversity of Melbourne
dc.contributor.institutionAnimal Anti Cruelty League
dc.contributor.institutionFaculty of Veterinary Medicine Bucharest
dc.contributor.institutionAnkara University
dc.contributor.institutionNational University of Asuncion
dc.contributor.institutionLilongwe Society for Protection and Care of Animals (LSPCA)
dc.contributor.institutionWellcome Sanger Institute
dc.contributor.institutionSan Diego
dc.date.accessioned2019-10-06T15:53:36Z
dc.date.available2019-10-06T15:53:36Z
dc.date.issued2019-08-02
dc.description.abstractThe canine transmissible venereal tumor (CTVT) is a cancer lineage that arose several millennia ago and survives by “metastasizing” between hosts through cell transfer. The somatic mutations in this cancer record its phylogeography and evolutionary history. We constructed a time-resolved phylogeny from 546 CTVT exomes and describe the lineage's worldwide expansion. Examining variation in mutational exposure, we identify a highly context-specific mutational process that operated early in the cancer's evolution but subsequently vanished, correlate ultraviolet-light mutagenesis with tumor latitude, and describe tumors with heritable hyperactivity of an endogenous mutational process. CTVT displays little evidence of ongoing positive selection, and negative selection is detectable only in essential genes. We illustrate how long-lived clonal organisms capture changing mutagenic environments, and reveal that neutral genetic drift is the dominant feature of long-term cancer evolution.en
dc.description.affiliationTransmissible Cancer Group Department of Veterinary Medicine University of Cambridge
dc.description.affiliationAnimal Management in Rural and Remote Indigenous Communities (AMRRIC)
dc.description.affiliationWorld Vets
dc.description.affiliationAnimal Shelter Stichting Dierenbescherming Suriname
dc.description.affiliationSikkim Anti-Rabies and Animal Health Programme Department of Animal Husbandry Livestock Fisheries and Veterinary Services Government of Sikkim
dc.description.affiliationRoyal (Dick) School of Veterinary Studies Roslin Institute University of Edinburgh Easter Bush Campus
dc.description.affiliationConserLab Animal Preventive Medicine Department Faculty of Animal and Veterinary Sciences University of Chile
dc.description.affiliationCorozal Veterinary Hospital University of Panamá
dc.description.affiliationSt. George's University
dc.description.affiliationNakuru District Veterinary Scheme Ltd
dc.description.affiliationAnimal Medical Centre
dc.description.affiliationInternational Animal Welfare Training Institute UC Davis School of Veterinary Medicine
dc.description.affiliationCentro Universitário de Rio Preto (UNIRP)
dc.description.affiliationDepartment of Clinical and Veterinary Surgery São Paulo State University (UNESP)
dc.description.affiliationLadybrand Animal Clinic
dc.description.affiliationVeterinary Clinic Sr. Dog's
dc.description.affiliationWorld Vets Latin America Veterinary Training Center
dc.description.affiliationNational Veterinary Research Institute
dc.description.affiliationAnimal Clinic
dc.description.affiliationIntermunicipal Stray Animals Care Centre (DIKEPAZ)
dc.description.affiliationAnimal Protection Society of Samoa
dc.description.affiliationFaculty of Veterinary Science University of Zulia
dc.description.affiliationVeterinary Clinic BIOCONTROL
dc.description.affiliationFaculty of Veterinary Medicine School of Health Sciences University of Thessaly
dc.description.affiliationVeterinary Clinic El Roble Animal Healthcare Network Faculty of Animal and Veterinary Sciences University of Chile
dc.description.affiliationOnevetGroup Hospital Veterinário Berna
dc.description.affiliationUniversidade Vila Velha
dc.description.affiliationVeterinary Clinic Zoovetservis
dc.description.affiliationÉcole Inter-états des Sciences et Médecine Vétérinaires de Dakar
dc.description.affiliationDepartment of Small Animal Medicine Faculty of Veterinary Medicine Utrecht University
dc.description.affiliationVetexpert Veterinary Group
dc.description.affiliationVeterinary Clinic Lopez Quintana
dc.description.affiliationClinique Veterinaire de Grand Fond Saint Gilles les Bains
dc.description.affiliationDepartment of Veterinary Sciences University of Messina
dc.description.affiliationFacultad de Medicina Veterinaria y Zootecnia Universidad Autónoma del Estado de México
dc.description.affiliationSchool of Veterinary Medicine Universidad de las Américas
dc.description.affiliationCancer Development and Innate Immune Evasion Lab Champalimaud Center for the Unknown
dc.description.affiliationTouray and Meyer Vet Clinic
dc.description.affiliationHillside Animal Hospital
dc.description.affiliationKampala Veterinary Surgery
dc.description.affiliationAsavet Veterinary Charities
dc.description.affiliationVets Beyond Borders
dc.description.affiliationFaculty of Veterinary Medicine Autonomous University of Yucatan
dc.description.affiliationLaboratorio de Patología Veterinaria Universidad de Caldas
dc.description.affiliationInterdisciplinary Centre of Research in Animal Health (CIISA) Faculty of Veterinary Medicine University of Lisbon
dc.description.affiliationFour Paws International
dc.description.affiliationHelp in Suffering
dc.description.affiliationVeterinary Clinic Dr José Rojas
dc.description.affiliationDepartment of Biotechnology Balochistan University of Information Technology Engineering and Management Sciences
dc.description.affiliationCorozal Veterinary Clinic
dc.description.affiliationVeterinary Clinic Vetmaster
dc.description.affiliationState Hospital of Veterinary Medicine
dc.description.affiliationJomo Kenyatta University of Agriculture and Technology
dc.description.affiliationLaboratory of Biomedicine and Regenerative Medicine Department of Clinical Sciences Faculty of Animal and Veterinary Sciences University of Chile
dc.description.affiliationFaculty of Veterinary and Agricultural Sciences University of Melbourne
dc.description.affiliationAnimal Anti Cruelty League
dc.description.affiliationClinical Sciences Department Faculty of Veterinary Medicine Bucharest
dc.description.affiliationDepartment of Pathology Faculty of Veterinary Medicine Ankara University
dc.description.affiliationFaculty of Veterinary Sciences National University of Asuncion
dc.description.affiliationLilongwe Society for Protection and Care of Animals (LSPCA)
dc.description.affiliationWellcome Sanger Institute
dc.description.affiliationDepartment of Cellular and Molecular Medicine University of California San Diego
dc.description.affiliationUnespDepartment of Clinical and Veterinary Surgery São Paulo State University (UNESP)
dc.description.sponsorshipGPD Charitable Trust
dc.description.sponsorshipLeverhulme Trust
dc.description.sponsorshipIdLeverhulme Trust: 102942/Z/13/A
dc.identifierhttp://dx.doi.org/10.1126/science.aau9923
dc.identifier.citationScience, v. 365, n. 6452, 2019.
dc.identifier.doi10.1126/science.aau9923
dc.identifier.issn1095-9203
dc.identifier.issn0036-8075
dc.identifier.scopus2-s2.0-85071029662
dc.identifier.urihttp://hdl.handle.net/11449/187992
dc.language.isoeng
dc.relation.ispartofScience
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.titleSomatic evolution and global expansion of an ancient transmissible cancer lineageen
dc.typeArtigo
dspace.entity.typePublication
unesp.author.lattes5256503293611165[16]
unesp.author.orcid0000-0001-6463-2144[16]

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