Current applications of drug delivery nanosystems associated with antimicrobial photodynamic therapy for oral infections

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dc.contributor.authorSilvestre, Amanda Letícia Polli [UNESP]
dc.contributor.authorDi Filippo, Leonardo Delello [UNESP]
dc.contributor.authorBesegato, João Felipe [UNESP]
dc.contributor.authorde Annunzio, Sarah Raquel [UNESP]
dc.contributor.authorAlmeida Furquim de Camargo, Bruna [UNESP]
dc.contributor.authorde Melo, Priscila Borges Gobbo [UNESP]
dc.contributor.authorRastelli, Alessandra Nara de Souza [UNESP]
dc.contributor.authorFontana, Carla Raquel [UNESP]
dc.contributor.authorChorilli, Marlus [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2021-06-25T10:45:12Z
dc.date.available2021-06-25T10:45:12Z
dc.date.issued2021-01-05
dc.description.abstractThe oral cavity is colonized by several species of microorganisms that can cause dental caries, periodontal diseases, candidiasis, endodontic infections, and, among other diseases related to the dental field. Conventional treatment consists of mechanical removal associated with systemic administration of antimicrobials, which can cause various side effects and microbial resistance. In this context, alternative therapies have been developed, including Antimicrobial Photodynamic Therapy (aPDT). For the improvement of therapy, the implementation of nanotechnology is very important to optimize the delivery system of the dyes or photosensitizers on biological targets. Besides, this combination provides a non-invasive treatment, better solubility and bioavailability, delivery to the target site, controlled release and protection against external and physical–chemical factors, low side effects, and, unlikely resistant species. Although, there are numerous researches on aPDT and nanotechnology, few review articles based on the combination of these three aspects: nanosystems, aPDT and oral infections are available. For this reason, this article aims to discuss the advances and advantages of this combination. Therefore, this article was divided into different types of nanosystems (organic and inorganic nanoparticles) associated with aPDT bringing a description of it is definitions, properties, and, applications in oral infections.en
dc.description.affiliationUNESP - São Paulo State University School of Pharmaceutical Sciences - Department of Drugs and Medicines
dc.description.affiliationUNESP - São Paulo State University School of Dentistry – Department of Restorative Dentistry
dc.description.affiliationUNESP - São Paulo State University School of Pharmaceutical Sciences - Department of Clinical Analysis
dc.description.affiliationUnespUNESP - São Paulo State University School of Pharmaceutical Sciences - Department of Drugs and Medicines
dc.description.affiliationUnespUNESP - São Paulo State University School of Dentistry – Department of Restorative Dentistry
dc.description.affiliationUnespUNESP - São Paulo State University School of Pharmaceutical Sciences - Department of Clinical Analysis
dc.identifierhttp://dx.doi.org/10.1016/j.ijpharm.2020.120078
dc.identifier.citationInternational Journal of Pharmaceutics, v. 592.
dc.identifier.doi10.1016/j.ijpharm.2020.120078
dc.identifier.issn1873-3476
dc.identifier.issn0378-5173
dc.identifier.scopus2-s2.0-85096554634
dc.identifier.urihttp://hdl.handle.net/11449/206869
dc.language.isoeng
dc.relation.ispartofInternational Journal of Pharmaceutics
dc.sourceScopus
dc.subjectaPDT
dc.subjectDental field
dc.subjectDrug delivery
dc.subjectNanoparticles
dc.subjectOral infections
dc.subjectReview
dc.titleCurrent applications of drug delivery nanosystems associated with antimicrobial photodynamic therapy for oral infectionsen
dc.typeResenha
unesp.author.orcid0000-0002-6698-0545[9]

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Artigos - Fármacos e Medicamentos - FCFAR
Artigos - Análises Clínicas - FCFAR