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Direct oral anticoagulants for treatment of deep vein thrombosis: Overview of systematic reviews

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dc.contributor.authorBrandão, Gustavo Muçouçah Sampaio
dc.contributor.authorCândido, Raissa Carolina Fonseca
dc.contributor.authorRollo, Hamilton de Almeida [UNESP]
dc.contributor.authorSobreira, Marcone Lima [UNESP]
dc.contributor.authorJunqueira, Daniela R.
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity of Alberta
dc.date.accessioned2019-10-06T16:09:11Z
dc.date.available2019-10-06T16:09:11Z
dc.date.issued2018-10-01
dc.description.abstractA number of limitations of standard therapy with warfarin for deep vein thrombosis (DVT) have been established. This overview of systematic reviews presents the baseline results for efficacy and safety of the new direct oral anticoagulants (DOACs) thrombin inhibitors, and activated factor X (Xa) inhibitors in patients with DVT. Searches were run on PubMed and the Cochrane Database of Systematic Reviews. Twenty-three studies were retrieved, and one systematic review was judged eligible. This review scored maximum according to AMSTAR criteria and included 7,596 patients for analysis of thrombin inhibitors and 16,356 patients for analysis of factor Xa inhibitors. The results of the meta-analysis indicate that DOACs are similar for DVT treatment when compared to standard treatment with warfarin. The incidence of major bleeding is somewhat lower in patients treated with factor Xa inhibitors and similar to standard therapy when treated with direct thrombin inhibitors.en
dc.description.affiliationUniversidade Federal de São Carlos – UFSCar Departamento de Medicina Saúde do Adulto e Idoso-Cirurgia
dc.description.affiliationUniversidade Federal de Minas Gerais – UFMG Centro de Estudos do Medicamento Departamento de Farmácia Social Faculdade de Farmácia
dc.description.affiliationUniversidade Estadual Paulista “Júlio de Mesquita Filho” – UNESP Faculdade de Medicina de Botucatu Departamento de Cirurgia e Ortopedia
dc.description.affiliationUniversity of Alberta
dc.description.affiliationUnespUniversidade Estadual Paulista “Júlio de Mesquita Filho” – UNESP Faculdade de Medicina de Botucatu Departamento de Cirurgia e Ortopedia
dc.format.extent310-317
dc.identifierhttp://dx.doi.org/10.1590/1677-5449.005518
dc.identifier.citationJornal Vascular Brasileiro, v. 17, n. 4, p. 310-317, 2018.
dc.identifier.doi10.1590/1677-5449.005518
dc.identifier.fileS1677-54492018000400310.pdf
dc.identifier.issn1677-7301
dc.identifier.issn1677-5449
dc.identifier.lattes9609324832591382
dc.identifier.scieloS1677-54492018000400310
dc.identifier.scopus2-s2.0-85058120557
dc.identifier.urihttp://hdl.handle.net/11449/188472
dc.language.isoeng
dc.relation.ispartofJornal Vascular Brasileiro
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectDeep venous thrombosis
dc.subjectDirect oral anticoagulants
dc.subjectSystematic review
dc.titleDirect oral anticoagulants for treatment of deep vein thrombosis: Overview of systematic reviewsen
dc.titleAnticoagulantes orais diretos para o tratamento da trombose venosa profunda: Revisão de revisões sistemáticaspt
dc.typeResenha
dspace.entity.typePublication
unesp.author.lattes9609324832591382
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentCirurgia e Ortopedia - FMBpt

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