Locus coeruleus noradrenergic neurons and CO2 drive to breathing

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dc.contributor.authorBiancardi, Vivian [UNESP]
dc.contributor.authorBicego, Kenia C. [UNESP]
dc.contributor.authorAlmeida, Maria Camila [UNESP]
dc.contributor.authorGargaglioni, Luciane H. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:59:59Z
dc.date.available2014-05-20T13:59:59Z
dc.date.issued2008-03-01
dc.description.abstractThe Locus coeruleus (LC) has been suggested as a CO2 chemoreceptor site in mammals. In the present study, we assessed the role of LC noradrenergic neurons in the cardiorespiratory and thermal responses to hypercapnia. To selectively destroy LC noradrenergic neurons, we administered 6-hydroxydopamine (6-OHDA) bilaterally into the LC of male Wistar rats. Control animals had vehicle (ascorbic acid) injected (sham group) into the LC. Pulmonary ventilation (plethysmograph), mean arterial pressure (MAP), heart rate (HR), and body core temperature (T-c, data loggers) were measured followed by 60 min of hypercapnic exposure (7% CO2 in air). To verify the correct placement and effectiveness of the chemical lesions, tyrosine hydroxylase immunoreactivity was performed. Hypercapnia caused an increase in pulmonary ventilation in all groups, which resulted from increases in respiratory frequency and tidal volume (V-T) in sham-operated and 6-OHDA-lesioned groups. The hypercapnic ventilatory response was significantly decreased in 6-OHDA-lesioned rats compared with sham group. This difference was due to a decreased V-T in 6-OHDA rats. LC chemical lesion or hypercapnia did not affect MAP, HR, and T-c. Thus, we conclude that LC noradrenergic neurons modulate hypercapnic ventilatory response but play no role in cardiovascular and thermal regulation under resting conditions.en
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Agr & Vet, Dept Morfol & Fis Anim, BR-14870000 Jaboticabal, SP, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Dept Zool, Rio Claro, SP, Brazil
dc.description.affiliationSão Paulo State Univ UNESP FCAV, Dept Anim Morphol & Physiol, Jaboticabal, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias Agr & Vet, Dept Morfol & Fis Anim, BR-14870000 Jaboticabal, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Dept Zool, Rio Claro, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP FCAV, Dept Anim Morphol & Physiol, Jaboticabal, SP, Brazil
dc.format.extent1119-1128
dc.identifierhttp://dx.doi.org/10.1007/s00424-007-0338-8
dc.identifier.citationPflugers Archiv-european Journal of Physiology. New York: Springer, v. 455, n. 6, p. 1119-1128, 2008.
dc.identifier.doi10.1007/s00424-007-0338-8
dc.identifier.issn0031-6768
dc.identifier.urihttp://hdl.handle.net/11449/21212
dc.identifier.wosWOS:000252640300015
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofPflugers Archiv: European Journal of Physiology
dc.relation.ispartofjcr2.765
dc.relation.ispartofsjr1,479
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectChemosensitivityen
dc.subjectA6en
dc.subjectHypercapniaen
dc.subjectVentilationen
dc.subjectPonsen
dc.subjectcatecholamineen
dc.titleLocus coeruleus noradrenergic neurons and CO2 drive to breathingen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt
unesp.departmentMorfologia e Fisiologia Animal - FCAVpt

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Artigos - Zoologia - IBRC
Jaboticabal - FCAV - Faculdade de Ciências Agrárias e Veterinárias