HLA-G liver expression and HLA-G extended haplotypes are associated with chronic hepatitis C in HIV-negative and HIV-coinfected patients

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Bertol, Bruna Cristina
Dias, Fabricio Cesar
Debortoli, Guilherme
Souto, Bruno Mendes
Mendonca, Priscila Baptista
Araujo, Roberta Chaves
Santana, Rodrigo Carvalho
Zambelli Ramalho, Leandra Naira
Castelli, Erick Cruz [UNESP]
Candolo Martinelli, Ana de Lourdes

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Elsevier B.V.


Chronic hepatitis C virus (HCV) infection induces liver damage and the HCV/Human Immunodeficiency Virus (HIV)-coinfection may further contribute to its progression. The HLA-G molecule inhibits innate and adaptive immunity and may be deleterious for chronically virus-infected cells. Thus we studied 204 HCV-mono-infected patients, 142 HCV/HIV-coinfected patients, 104 HIV-mono-infected patients and 163 healthy subjects. HLA-G liver expression was similarly induced in HCV and HCV/HIV specimens, increasing with advanced fibrosis and necroinflammatory activity, and with increased levels of liver function-related enzymes. Plasma soluble HLA-G (sHLA-G) levels were higher in HCV/HIV patients compared to HCV, HIV and to healthy individuals. sHLA-G continued to be higher in coinfected patients even after stratification of samples according to degree of liver fibrosis and necroinflammatory activity when compared to mono-infected patients. Some HLA-G gene haplo-types differentiated patient groups and presented few associations with liver and plasma HLA-G expression. HLA-G thus may help to distinguish patient groups.



Human leukocyte antigen-G, Soluble HLA-G, HLA-G polymorphisms, HCV/HIV-coinfection, Antiviral immunity

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Clinical Immunology. San Diego: Academic Press Inc Elsevier Science, v. 217, 12 p., 2020.