Cardiovascular Complications following Chronic Treatment with Cocaine and Testosterone in Adolescent Rats

dc.contributor.authorEngi, Sheila A. [UNESP]
dc.contributor.authorCruz, Fabio C.
dc.contributor.authorLeao, Rodrigo M.
dc.contributor.authorSpolidório, Luis Carlos [UNESP]
dc.contributor.authorPlaneta, Cleopatra da Silva [UNESP]
dc.contributor.authorCrestani, Carlos Cesar [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionNIDA
dc.date.accessioned2015-03-18T15:56:02Z
dc.date.available2015-03-18T15:56:02Z
dc.date.issued2014-08-14
dc.description.abstractConcomitant use of anabolic androgenic steroids and cocaine has increased in the last years. However, the effects of chronic exposure to these substances during adolescence on cardiovascular function are unknown. Here, we investigated the effects of treatment for 10 consecutive days with testosterone and cocaine alone or in combination on basal cardiovascular parameters, baroreflex activity, hemodynamic responses to vasoactive agents, and cardiac morphology in adolescent rats. Administration of testosterone alone increased arterial pressure, reduced heart rate (HR), and exacerbated the tachycardiac baroreflex response. Cocaine-treated animals showed resting bradycardia without changes in arterial pressure and baroreflex activity. Combined treatment with testosterone and cocaine did not affect baseline arterial pressure and HR, but reduced baroreflex-mediated tachycardia. None of the treatments affected arterial pressure response to either vasoconstrictor or vasodilator agents. Also, heart to body ratio and left and right ventricular wall thickness were not modified by drug treatments. However, histological analysis of left ventricular sections of animals subjected to treatment with testosterone and cocaine alone and combined showed a greater spacing between cardiac muscle fibers, dilated blood vessels, and fibrosis. These data show important cardiovascular changes following treatment with testosterone in adolescent rats. However, the results suggest that exposure to cocaine alone or combined with testosterone during adolescence minimally affect cardiovascular function.en
dc.description.affiliationUNESP, Sch Pharmaceut Sci, Dept Nat Act Principles & Toxicol, Pharmacol Lab, Araraquara, SP, Brazil
dc.description.affiliationUNESP, Grad Program Physiol Sci, Joint UFSCar, Sao Carlos, SP, Brazil
dc.description.affiliationNIDA, Behav Neurosci Branch, Intramural Res Program, US NIH,Dept Hlth & Human Serv, Baltimore, MD USA
dc.description.affiliationUNESP, Sch Dent Araraquara, Dept Physiol & Pathol, Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Sch Pharmaceut Sci, Dept Nat Act Principles & Toxicol, Pharmacol Lab, Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Grad Program Physiol Sci, Joint UFSCar, Sao Carlos, SP, Brazil
dc.description.affiliationUnespUNESP, Sch Dent Araraquara, Dept Physiol & Pathol, Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipPADC-School of Pharmaceutical Sciences-Sao Paulo State University
dc.description.sponsorshipIdFAPESP: 10/16192-8
dc.description.sponsorshipIdFAPESP: 12/14376-0
dc.description.sponsorshipIdFAPESP: 12/50549-6
dc.format.extent11
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0105172
dc.identifier.citationPlos One. San Francisco: Public Library Science, v. 9, n. 8, 11 p., 2014.
dc.identifier.doi10.1371/journal.pone.0105172
dc.identifier.fileWOS000341017000102.pdf
dc.identifier.issn1932-6203
dc.identifier.lattes2640929291808415
dc.identifier.lattes2514762545280942
dc.identifier.orcid0000-0002-1378-6327
dc.identifier.urihttp://hdl.handle.net/11449/117399
dc.identifier.wosWOS:000341017000102
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.relation.ispartofjcr2.766
dc.relation.ispartofsjr1,164
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleCardiovascular Complications following Chronic Treatment with Cocaine and Testosterone in Adolescent Ratsen
dc.typeArtigo
dcterms.rightsHolderPublic Library Science
unesp.author.lattes2640929291808415
unesp.author.lattes1117432571971568[6]
unesp.author.lattes2514762545280942[5]
unesp.author.orcid0000-0002-1942-858X[6]
unesp.author.orcid0000-0002-1378-6327[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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