FoxO3 and oxidative stress: a multifaceted role in cellular adaptation

dc.contributor.authorBernardo, Victoria Simões [UNESP]
dc.contributor.authorTorres, Flaviene Felix [UNESP]
dc.contributor.authorda Silva, Danilo Grünig Humberto [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Federal de Mato Grosso do Sul (UFMS)
dc.description.abstractOxidative stress is a major cause of morbidity and mortality in human health and disease. In this review, we focus on the Forkhead Box (Fox) subclass O3 (FoxO3), an extensively studied transcription factor that plays a pleiotropic role in a wide range of physiological and pathological processes by regulating multiple gene regulatory networks involved in the modulation of numerous aspects of cellular metabolism, including fuel metabolism, cell death, and stress resistance. This review will also focus on regulatory mechanisms of FoxO3 expression and activity, such as crucial post-translational modifications and non-coding RNAs. Moreover, this work discusses and evidences some pathways to how this transcription factor and reactive oxygen species regulate each other, which may lead to the pathogenesis of various types of diseases. Therefore, in addition to being a promising therapeutic target, the FoxO3-regulated signaling pathways can also be used as reliable diagnostic and prognostic biomarkers and indicators for drug responsiveness.en
dc.description.affiliationDepartment of Biology Universidade Estadual Paulista (UNESP)
dc.description.affiliationUniversidade Federal de Mato Grosso Do Sul (CPTL/UFMS), Campus de Três Lagoas, Avenida Ranulpho Marques Leal, 3484, Mato Grosso Do Sul, Distrito Industrial–Post code
dc.description.affiliationUnespDepartment of Biology Universidade Estadual Paulista (UNESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdCNPq: 406700/2021-4
dc.description.sponsorshipIdCAPES: Finance Code 001
dc.identifier.citationJournal of Molecular Medicine, v. 101, n. 1-2, p. 83-99, 2023.
dc.relation.ispartofJournal of Molecular Medicine
dc.subjectPathological processes
dc.subjectReactive oxygen species
dc.subjectRegulatory networks
dc.subjectTherapeutic target
dc.titleFoxO3 and oxidative stress: a multifaceted role in cellular adaptationen