Prevalence and antifungal resistance profile of Candida spp. oral isolates from patients with type 1 and 2 diabetes mellitus

Página do item simplificado
dc.contributor.authorBremenkamp, R. M. [UNESP]
dc.contributor.authorCaris, A. R. [UNESP]
dc.contributor.authorJorge, A. O. C. [UNESP]
dc.contributor.authorBack Brito, Graziella Nuernberg [UNESP]
dc.contributor.authorMota, A. J. [UNESP]
dc.contributor.authorBalducci, Ivan [UNESP]
dc.contributor.authorBrighenti, Fernanda Lourenção [UNESP]
dc.contributor.authorKoga-Ito, C. Y. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T14:04:36Z
dc.date.available2014-05-20T14:04:36Z
dc.date.issued2011-06-01
dc.description.abstractObjective: The goal of the study was to measure the prevalence of Candida spp. in the oral cavity of patients with diabetes types 1 and 2 when compared to healthy individuals and to study antifungal resistance profile of the isolates.Design: There were 162 subjects in the study: diabetes type 1 (n = 39); control group 1 (n = 50): healthy individuals matched in gender, age, and oral conditions to diabetes type 1 patients; diabetes type 2 (n = 37); control group 2 (n = 36) who were matched to each patient of the diabetes type 2 group. Stimulated saliva was collected and isolates were identified with phenotypic tests. The presence of C. dubliniensis was determined by multiplex PCR.Results: There were no statistically significant differences in Candida spp. frequency between the diabetes 1 group and its control (p = 0.443) nor between the diabetes 2 group and its control (p = 0.429). C. albicans was the most frequently isolated yeast in all groups. In the diabetes groups, C. stellatoidea, C. parapsilosis, C. tropicalis, C. lipolytica, C. glabrata, and C. krusei were also identified. Additionally, in control groups, C. kefyr was also detected. None of the isolates were resistant to amphotericin B and flucytosine. A low percentage of the isolates were resistant to ketoconazole.Conclusions: No differences were detected in colonization of Candida spp. oral isolates from type 1 and type 2 diabetes when compared to matched controls. The antifungal resistance of Candida spp. isolates for ketoconazole from type 1 diabetes patients was significantly higher than that of its matched control. (C) 2010 Published by Elsevier Ltd.en
dc.description.affiliationUniv Estadual Paulista, UNESP, Sao Jose dos Campos Dent Sch, Dept Biosci & Oral Diag Microbiol & Immunol, BR-12245000 Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Sao Jose dos Campos Dent Sch, Dept Social Dent, BR-12245000 Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Sao Jose dos Campos Dent Sch, Dept Biosci & Oral Diag Microbiol & Immunol, BR-12245000 Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Sao Jose dos Campos Dent Sch, Dept Social Dent, BR-12245000 Sao Jose Dos Campos, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 04/01602-5
dc.format.extent549-555
dc.identifierhttp://dx.doi.org/10.1016/j.archoralbio.2010.11.018
dc.identifier.citationArchives of Oral Biology. Oxford: Pergamon-Elsevier B.V. Ltd, v. 56, n. 6, p. 549-555, 2011.
dc.identifier.doi10.1016/j.archoralbio.2010.11.018
dc.identifier.issn0003-9969
dc.identifier.lattes0053567153623569
dc.identifier.lattes6065636367717382
dc.identifier.lattes6543563161403421
dc.identifier.orcid0000-0002-4470-5171
dc.identifier.orcid0000-0002-2416-2173
dc.identifier.urihttp://hdl.handle.net/11449/22670
dc.identifier.wosWOS:000291905300004
dc.language.isoeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relation.ispartofArchives of Oral Biology
dc.relation.ispartofjcr2.050
dc.relation.ispartofsjr0,752
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectCandida spp.en
dc.subjectOral isolatesen
dc.subjectDiabetes mellitusen
dc.subjectAntifungal drugen
dc.titlePrevalence and antifungal resistance profile of Candida spp. oral isolates from patients with type 1 and 2 diabetes mellitusen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderPergamon-Elsevier B.V. Ltd
unesp.author.lattes0053567153623569[3]
unesp.author.lattes6065636367717382[7]
unesp.author.lattes6543563161403421[8]
unesp.author.orcid0000-0002-1747-6158[3]
unesp.author.orcid0000-0002-4470-5171[7]
unesp.author.orcid0000-0002-2416-2173[8]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campospt

Arquivos

Licença do Pacote
Agora exibindo 1 - 2 de 2
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:

Coleções

Artigos - Odontologia Social e Clínica Infantil - ICT