Flavonols from Pterogyne nitens and their evaluation as myeloperoxidase inhibitors
dc.contributor.author | Regasini, Luis Octavio [UNESP] | |
dc.contributor.author | Rebuglio Vellosa, Jose Carlos [UNESP] | |
dc.contributor.author | Siqueira Silva, Dulce Helena [UNESP] | |
dc.contributor.author | Furlan, Maysa [UNESP] | |
dc.contributor.author | Mascarenhas de Oliveira, Olga Maria [UNESP] | |
dc.contributor.author | Khalil, Najeh Maissar [UNESP] | |
dc.contributor.author | Brunetti, Iguatemy Lourenço [UNESP] | |
dc.contributor.author | Marx Young, Maria Claudia | |
dc.contributor.author | Barreiro, Eliezer Jesus | |
dc.contributor.author | Bolzani, Vanderlan da Silva [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Universidade Federal do Rio de Janeiro (UFRJ) | |
dc.date.accessioned | 2014-05-20T14:17:35Z | |
dc.date.available | 2014-05-20T14:17:35Z | |
dc.date.issued | 2008-05-01 | |
dc.description.abstract | A myeloperoxidase inhibitory kaempferol derivative, namely pterogynoside (1), was isolated from fruits of Pterogyne nitens, along with six known flavonols, kaempferol, afzelin, kaempferitrin, quercetin, isoquercetrin and rutin. The structures of all compounds were elucidated primarily from 1D and 2D NMR spectroscopic analyses, as well as by high resolution mass spectrometry. All flavonols were screened to identify secondary metabolites as potential myeloperoxidase (MPO) inhibitors, and at concentrations of 0.50-50 nM, quercetin (5), isoquercitrin (6) and rutin (7) exhibited strong inhibitory effects with IC(50) values of 1.22 +/- 0.01, 3.75 +/- 0.02 and 3.60 +/- 0.02, respectively. The MPO activity detected for the new derivative 1 was markedly decreased (IC(50) 10.3 +/- 0.03) when compared with known flavonols 5-7, and interestingly increased when tested against ABTS scavenging activity. (C) 2008 Published by Elsevier Ltd. | en |
dc.description.affiliation | Univ Estadual Paulista, Inst Quim, Dept Bioquim & Tecnol Quim, BR-14801900 Araraquara, SP, Brazil | |
dc.description.affiliation | UNESP, Fac Ciencias Farmaceut, Dept Anal Clin, BR-14801902 Araraquara, SP, Brazil | |
dc.description.affiliation | Secao Fisiol & Bioquim Plantas, Inst Bot, BR-01061970 São Paulo, SP, Brazil | |
dc.description.affiliation | Univ Fed Rio de Janeiro, LASSBIO, Fac Farm, BR-21944910 Rio de Janeiro, Brazil | |
dc.description.affiliation | Univ Estadual Paulista, Inst Quim, NuBBE Prod Nat, BR-14801970 Araraquara, SP, Brazil | |
dc.description.affiliationUnesp | Univ Estadual Paulista, Inst Quim, Dept Bioquim & Tecnol Quim, BR-14801900 Araraquara, SP, Brazil | |
dc.description.affiliationUnesp | UNESP, Fac Ciencias Farmaceut, Dept Anal Clin, BR-14801902 Araraquara, SP, Brazil | |
dc.description.affiliationUnesp | Univ Estadual Paulista, Inst Quim, NuBBE Prod Nat, BR-14801970 Araraquara, SP, Brazil | |
dc.format.extent | 1739-1744 | |
dc.identifier | http://dx.doi.org/10.1016/j.phytochem.2008.01.006 | |
dc.identifier.citation | Phytochemistry. Oxford: Pergamon-Elsevier B.V. Ltd, v. 69, n. 8, p. 1739-1744, 2008. | |
dc.identifier.doi | 10.1016/j.phytochem.2008.01.006 | |
dc.identifier.issn | 0031-9422 | |
dc.identifier.lattes | 4702004904231248 | |
dc.identifier.lattes | 1308042794786872 | |
dc.identifier.lattes | 4484083685251673 | |
dc.identifier.uri | http://hdl.handle.net/11449/25268 | |
dc.identifier.wos | WOS:000256782100013 | |
dc.language.iso | eng | |
dc.publisher | Pergamon-Elsevier B.V. Ltd | |
dc.relation.ispartof | Phytochemistry | |
dc.relation.ispartofjcr | 3.186 | |
dc.relation.ispartofsjr | 1,048 | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | Pterogyne nitens | en |
dc.subject | Fabaceae | en |
dc.subject | acylated flavonol | en |
dc.subject | myeloperoxidase | en |
dc.subject | antioxidant | en |
dc.title | Flavonols from Pterogyne nitens and their evaluation as myeloperoxidase inhibitors | en |
dc.type | Artigo | |
dcterms.license | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
dcterms.rightsHolder | Pergamon-Elsevier B.V. Ltd | |
unesp.author.lattes | 4702004904231248 | |
unesp.author.lattes | 1308042794786872 | |
unesp.author.lattes | 4484083685251673 | |
unesp.campus | Universidade Estadual Paulista (Unesp), Instituto de Química, Araraquara | pt |
unesp.campus | Universidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquara | pt |
unesp.department | Análises Clínicas - FCF | pt |
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