Flavonols from Pterogyne nitens and their evaluation as myeloperoxidase inhibitors

dc.contributor.authorRegasini, Luis Octavio [UNESP]
dc.contributor.authorRebuglio Vellosa, Jose Carlos [UNESP]
dc.contributor.authorSiqueira Silva, Dulce Helena [UNESP]
dc.contributor.authorFurlan, Maysa [UNESP]
dc.contributor.authorMascarenhas de Oliveira, Olga Maria [UNESP]
dc.contributor.authorKhalil, Najeh Maissar [UNESP]
dc.contributor.authorBrunetti, Iguatemy Lourenço [UNESP]
dc.contributor.authorMarx Young, Maria Claudia
dc.contributor.authorBarreiro, Eliezer Jesus
dc.contributor.authorBolzani, Vanderlan da Silva [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.date.accessioned2014-05-20T14:17:35Z
dc.date.available2014-05-20T14:17:35Z
dc.date.issued2008-05-01
dc.description.abstractA myeloperoxidase inhibitory kaempferol derivative, namely pterogynoside (1), was isolated from fruits of Pterogyne nitens, along with six known flavonols, kaempferol, afzelin, kaempferitrin, quercetin, isoquercetrin and rutin. The structures of all compounds were elucidated primarily from 1D and 2D NMR spectroscopic analyses, as well as by high resolution mass spectrometry. All flavonols were screened to identify secondary metabolites as potential myeloperoxidase (MPO) inhibitors, and at concentrations of 0.50-50 nM, quercetin (5), isoquercitrin (6) and rutin (7) exhibited strong inhibitory effects with IC(50) values of 1.22 +/- 0.01, 3.75 +/- 0.02 and 3.60 +/- 0.02, respectively. The MPO activity detected for the new derivative 1 was markedly decreased (IC(50) 10.3 +/- 0.03) when compared with known flavonols 5-7, and interestingly increased when tested against ABTS scavenging activity. (C) 2008 Published by Elsevier Ltd.en
dc.description.affiliationUniv Estadual Paulista, Inst Quim, Dept Bioquim & Tecnol Quim, BR-14801900 Araraquara, SP, Brazil
dc.description.affiliationUNESP, Fac Ciencias Farmaceut, Dept Anal Clin, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationSecao Fisiol & Bioquim Plantas, Inst Bot, BR-01061970 São Paulo, SP, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, LASSBIO, Fac Farm, BR-21944910 Rio de Janeiro, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Quim, NuBBE Prod Nat, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim, Dept Bioquim & Tecnol Quim, BR-14801900 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Fac Ciencias Farmaceut, Dept Anal Clin, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim, NuBBE Prod Nat, BR-14801970 Araraquara, SP, Brazil
dc.format.extent1739-1744
dc.identifierhttp://dx.doi.org/10.1016/j.phytochem.2008.01.006
dc.identifier.citationPhytochemistry. Oxford: Pergamon-Elsevier B.V. Ltd, v. 69, n. 8, p. 1739-1744, 2008.
dc.identifier.doi10.1016/j.phytochem.2008.01.006
dc.identifier.issn0031-9422
dc.identifier.lattes4702004904231248
dc.identifier.lattes1308042794786872
dc.identifier.lattes4484083685251673
dc.identifier.urihttp://hdl.handle.net/11449/25268
dc.identifier.wosWOS:000256782100013
dc.language.isoeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relation.ispartofPhytochemistry
dc.relation.ispartofjcr3.186
dc.relation.ispartofsjr1,048
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectPterogyne nitensen
dc.subjectFabaceaeen
dc.subjectacylated flavonolen
dc.subjectmyeloperoxidaseen
dc.subjectantioxidanten
dc.titleFlavonols from Pterogyne nitens and their evaluation as myeloperoxidase inhibitorsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderPergamon-Elsevier B.V. Ltd
unesp.author.lattes4702004904231248
unesp.author.lattes1308042794786872
unesp.author.lattes4484083685251673
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentAnálises Clínicas - FCFpt

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