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Restriction fragment length polymorphism (RFLP) in Exon 2 of the BoLA-DRB3 gene in South American cattle

dc.contributor.authorMiretti, M. M.
dc.contributor.authorFerro, J. A.
dc.contributor.authorLara, M. A.
dc.contributor.authorContel, EPB
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionIZ
dc.date.accessioned2014-05-20T13:17:30Z
dc.date.available2014-05-20T13:17:30Z
dc.date.issued2001-10-01
dc.description.abstractThe Bola-DRB3 gene participates in the development of the immune response and is highly polymorphic. For these reasons, it has been a candidate gene in studies of the genetic basis of disease resistance and in population genetic analysis. South American native cattle breeds have been widely replaced by improved exotic breeds leading to a loss of genetic resources. In particular South American native breeds have high levels of fertility and disease resistance. This work describes genetic variability in the BoLA-DRB3 gene in native (Caracu, Pantaneiro, Argentinean Creole) and exotic (Holstein, Jersey, Nelore, Gir) cattle breeds in Brazil and Argentina. PCR-RFLP alleles were identified by combining the restriction patterns for the BoLA-DRB3.2 locus obtained with RsaI, BstY, and HaeIII restriction enzymes. Allelic frequencies and deviations from the Hardy-Weinberg equilibrium were also calculated. Analysis of the 24 BoLA-DRB3 PCR-RFLP alleles identified showed differences in the allele distributions among breeds.en
dc.description.affiliationUNESP, FCAV, Dept Technol, LBM, BR-14870000 Jaboticabal, SP, Brazil
dc.description.affiliationUSP, FMRP, Dept Genet, Ribeirao Preto, Brazil
dc.description.affiliationIZ, Ctr Genet & Reprod, Nova Odessa, SP, Brazil
dc.description.affiliationUnespUNESP, FCAV, Dept Technol, LBM, BR-14870000 Jaboticabal, SP, Brazil
dc.format.extent311-324
dc.identifierhttp://dx.doi.org/10.1023/A:1012204829894
dc.identifier.citationBiochemical Genetics. New York: Kluwer Academic/plenum Publ, v. 39, n. 9-10, p. 311-324, 2001.
dc.identifier.doi10.1023/A:1012204829894
dc.identifier.issn0006-2928
dc.identifier.lattes0147241723612464
dc.identifier.urihttp://hdl.handle.net/11449/3939
dc.identifier.wosWOS:000172140300003
dc.language.isoeng
dc.publisherKluwer Academic/plenum Publ
dc.relation.ispartofBiochemical Genetics
dc.relation.ispartofjcr1.927
dc.relation.ispartofsjr0,507
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectMHCpt
dc.subjectDRB3pt
dc.subjectBovinept
dc.subjectgenetic variabilitypt
dc.titleRestriction fragment length polymorphism (RFLP) in Exon 2 of the BoLA-DRB3 gene in South American cattleen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights
dcterms.rightsHolderKluwer Academic/plenum Publ
unesp.author.lattes0147241723612464
unesp.author.orcid0000-0002-3966-1303[2]
unesp.author.orcid0000-0001-5144-8858[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt
unesp.departmentTecnologia - FCAVpt

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