Publicação:
Influence of Helicobacter pylori infection on the expression of MLH1 and MGMT in patients with chronic gastritis and gastric cancer

Página do item simplificado
dc.contributor.authorBartchewsky, W.
dc.contributor.authorMartini, M. R.
dc.contributor.authorSquassoni, A. C.
dc.contributor.authorAlvarez, M. C.
dc.contributor.authorLadeira, M. S. P. [UNESP]
dc.contributor.authorSalvadori, Daisy Maria Favero [UNESP]
dc.contributor.authorTrevisan, M. A.
dc.contributor.authorPedrazzoli, J.
dc.contributor.authorRibeiro, M. L.
dc.contributor.institutionUniv Sao Francisco
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionLab MULTIPAT
dc.date.accessioned2014-05-20T13:33:18Z
dc.date.available2014-05-20T13:33:18Z
dc.date.issued2009-06-01
dc.description.abstractThe aim of the present study was to evaluate the influence of Helicobacter pylori on MLH1 and MGMT mRNA levels in patients with chronic gastritis and gastric cancer. The study included 217 patients, of which 26 were uninfected, 127 had chronic gastritis and were H. pylori-positive, and 64 had gastric cancer. Bacterial genotypes were evaluated by polymerase chain reaction (PCR), and the expression levels of MLH1 and MGMT were determined by quantitative real-time PCR and immunohistochemistry. There was an association between infection with cagA, vacA s1m1 strains and gastric cancer development. When the gastric epithelium and associated inflammation were examined for expression of MLH1 and MGMT, an overall increase in expression was observed. on the other hand, these levels decrease significantly among gastric cancer patients. The loss of MLH1 and MGMT expression in gastric cancer patients suggests that it is not an early event in H. pylori-associated gastric carcinogenesis.en
dc.description.affiliationUniv Sao Francisco, Unidade Integrada Farmacol & Gastroenterol, Braganca Paulista, SP, Brazil
dc.description.affiliationUNESP, Dpto Clin Med, Botucatu, SP, Brazil
dc.description.affiliationUNESP, Dpto Patol, Botucatu, SP, Brazil
dc.description.affiliationLab MULTIPAT, Campinas, SP, Brazil
dc.description.affiliationUnespUNESP, Dpto Clin Med, Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Dpto Patol, Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 05/56736-9
dc.format.extent591-597
dc.identifierhttp://dx.doi.org/10.1007/s10096-008-0676-2
dc.identifier.citationEuropean Journal of Clinical Microbiology & Infectious Diseases. New York: Springer, v. 28, n. 6, p. 591-597, 2009.
dc.identifier.doi10.1007/s10096-008-0676-2
dc.identifier.issn0934-9723
dc.identifier.lattes5051118752980903
dc.identifier.urihttp://hdl.handle.net/11449/11388
dc.identifier.wosWOS:000266372700005
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofEuropean Journal of Clinical Microbiology & Infectious Diseases
dc.relation.ispartofjcr2.537
dc.relation.ispartofsjr1,312
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleInfluence of Helicobacter pylori infection on the expression of MLH1 and MGMT in patients with chronic gastritis and gastric canceren
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
dspace.entity.typePublication
unesp.author.lattes5051118752980903
unesp.author.orcid0000-0003-4529-7832[9]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentClínica Médica - FMBpt
unesp.departmentPatologia - FMBpt

Arquivos

Licença do Pacote

Agora exibindo 1 - 2 de 2
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:

Coleções

Botucatu - FMB - Faculdade de Medicina