The critical barrier to progress in dentine bonding with the etch-and-rinse technique

dc.contributor.authorBrackett, M. G.
dc.contributor.authorLi, N.
dc.contributor.authorBrackett, W. W.
dc.contributor.authorSword, R. J.
dc.contributor.authorQi, Y. P.
dc.contributor.authorNiu, L. N.
dc.contributor.authorPucci, C. R. [UNESP]
dc.contributor.authorDib, A.
dc.contributor.authorPashley, D. H.
dc.contributor.authorTay, F. R.
dc.contributor.institutionMed Coll Georgia
dc.contributor.institutionFujian Univ Tradit Chinese Med
dc.contributor.institutionSun Yat Sen Univ
dc.contributor.institutionFourth Mil Med Univ
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionBenemerita Univ Autonoma Puebla
dc.date.accessioned2014-05-20T14:05:23Z
dc.date.available2014-05-20T14:05:23Z
dc.date.issued2011-03-01
dc.description.abstractObjectives: The lack of durability in resin-dentine bonds led to the use of chlorhexidine as MMP-inhibitor to prevent the degradation of hybrid layers. Biomimetic remineralisation is a concept-proven approach in preventing the degradation of resin-dentine bonds. The purpose of this study is to examine the integrity of aged resin-dentine interfaces created with a nanofiller-containing etch-and-rinse adhesive after the application of these two approaches.Methods: The more established MMP-inhibition approach was examined using a parallel in vivo and in vitro ageing design to facilitate comparison with the biomimetic remineralisation approach using an in vitro ageing design. Specimens bonded without chlorhexidine exhibited extensive degradation of the hybrid layer after 12 months of in vivo ageing.Results: Dissolution of nanofillers could be seen within a water-rich zone within the adhesive layer. Although specimens bonded with chlorhexidine exhibited intact hybrid layers, water-rich regions remained in those hybrid layers and degradation of nanofillers occurred within the adhesive layer. Specimens subjected to in vitro biomimetic remineralisation followed by in vitro ageing demonstrated intrafibrillar collagen remineralisation within hybrid layers and deposition of mineral nanocrystals in nanovoids within the adhesive.Conclusions: The impact was realized by understanding the lack of an inherent mechanism to remove water from resin-dentine interfaces as the critical barrier to progress in bonding with the etch-and-rinse technique. The experimental biomimetic remineralisation strategy offers a creative solution for incorporating a progressive hydration mechanism to achieve this goal, which warrants its translation into a clinically applicable technique. (C) 2011 Elsevier Ltd. All rights reserved.en
dc.description.affiliationMed Coll Georgia, Sch Dent, Dept Endodont, Augusta, GA 30912 USA
dc.description.affiliationMed Coll Georgia, Sch Dent, Dept Oral Rehabil, Augusta, GA 30912 USA
dc.description.affiliationFujian Univ Tradit Chinese Med, Coll Osteoped & Traumatol, Fuzhou, Fujian, Peoples R China
dc.description.affiliationSun Yat Sen Univ, Guanghua Sch Stomatol, Dept Operat Dent & Endodont, Guangzhou 510275, Guangdong, Peoples R China
dc.description.affiliationFourth Mil Med Univ, Sch Stomatol, Dept Prosthodont, Xian 710032, Peoples R China
dc.description.affiliationUniv Estadual Paulista, UNESP, Fac Odontol Sao Jose dos Campos, São Paulo, Brazil
dc.description.affiliationBenemerita Univ Autonoma Puebla, Fac Estomatol, Puebla, Mexico
dc.description.affiliationMed Coll Georgia, Sch Dent, Dept Oral Biol, Augusta, GA 30912 USA
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Fac Odontol Sao Jose dos Campos, São Paulo, Brazil
dc.description.sponsorshipBenemerita Universidad Autonoma de Puebla, Mexico
dc.description.sponsorshipNational Institute of Dental and Craniofacial Research
dc.description.sponsorshipIdR01 DE015306-06
dc.description.sponsorshipIdR21 DE019213-01
dc.format.extent238-248
dc.identifierhttp://dx.doi.org/10.1016/j.jdent.2010.12.009
dc.identifier.citationJournal of Dentistry. Oxford: Elsevier B.V., v. 39, n. 3, p. 238-248, 2011.
dc.identifier.doi10.1016/j.jdent.2010.12.009
dc.identifier.issn0300-5712
dc.identifier.lattes1754020652874850
dc.identifier.orcid0000-0003-4830-0400
dc.identifier.urihttp://hdl.handle.net/11449/22944
dc.identifier.wosWOS:000288890600008
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Dentistry
dc.relation.ispartofjcr3.770
dc.relation.ispartofsjr1,919
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAgeingen
dc.subjectBiomimetic remineralisationen
dc.subjectChlorhexidineen
dc.subjectDegradationen
dc.subjectHybrid layeren
dc.subjectMatrix metalloproteinaseen
dc.titleThe critical barrier to progress in dentine bonding with the etch-and-rinse techniqueen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes1754020652874850[7]
unesp.author.orcid0000-0003-4830-0400[7]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campospt

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