Feline obesity causes hematological and biochemical changes and oxidative stress – a pilot study

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dc.contributor.authorMartins, Tainara de Oliveira
dc.contributor.authorRamos, Rebecca Cápera
dc.contributor.authorPossidonio, Geovana
dc.contributor.authorBosculo, Maria Rachel Melo
dc.contributor.authorOliveira, Paula Lima [UNESP]
dc.contributor.authorCosta, Leticia Ramos
dc.contributor.authorZamboni, Vinicius Aquiles Gomes
dc.contributor.authorMarques, Marcel Gambin
dc.contributor.authorde Almeida, Breno Fernando Martins [UNESP]
dc.contributor.institutionUniversity Center of the Integrated Faculties of Ourinhos (Unifio)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-03-01T21:16:20Z
dc.date.available2023-03-01T21:16:20Z
dc.date.issued2022-01-01
dc.description.abstractObesity, an extremely important factor in feline clinical practice, is estimated to affect up to one third of the feline population. Moreover, it can trigger chronic inflammation, which could predispose to oxidative stress by increasing reactive oxygen species, thereby generating potentially irreversible cellular damage. This study analyzed hematological, biochemical and oxidative stress profiles at various degrees of feline obesity. Forty-five cats were selected and divided into three groups: control (n = 17), overweight (n = 13) and obese (n = 15), after clinical and laboratory evaluation and body condition score. Biochemical and oxidative stress analyses were performed using a photocolorimeter and hematological analyses were performed in a veterinary cell counter. Obese cats showed increased mean corpuscular volume (MCV), red cell distribution width (RDW), HDL cholesterol and triglycerides and decreased activity of gamma-glutamyl transferase (GGT) than control cats, although within the reference ranges for the species. As for oxidative stress, obese cats showed higher total antioxidant capacity (TAC), by the inhibition of 2,2’-Azino-Bis-3-Ethylbenzthiazoline-6-Sulfonic Acid (ABTS), inhibition of ABTS associated with horseradish peroxidase (ABTS + HRP), cupric ion reducing antioxidant capacity (CUPRAC) and ferric reducing antioxidant power (FRAP) methods, while overweight cats had a higher TAC-ABTS + HRP and TAC-FRAP than control cats. We conclude that the conditions of natural obesity and overweight in the feline species alter its hematological, biochemical and oxidative stress parameters.en
dc.description.affiliationRoque Quagliato Veterinary Hospital University Center of the Integrated Faculties of Ourinhos (Unifio), Rodovia BR 153, km 338, Bairro Água do Cateto, SP
dc.description.affiliationFaculty of Veterinary Medicine of Araçatuba São Paulo State University (FMVA-Unesp), SP
dc.description.affiliationUnespFaculty of Veterinary Medicine of Araçatuba São Paulo State University (FMVA-Unesp), SP
dc.identifierhttp://dx.doi.org/10.1007/s11259-022-09940-5
dc.identifier.citationVeterinary Research Communications.
dc.identifier.doi10.1007/s11259-022-09940-5
dc.identifier.issn1573-7446
dc.identifier.issn0165-7380
dc.identifier.scopus2-s2.0-85133296422
dc.identifier.urihttp://hdl.handle.net/11449/241675
dc.language.isoeng
dc.relation.ispartofVeterinary Research Communications
dc.sourceScopus
dc.subjectAntioxidants
dc.subjectCats
dc.subjectComplete blood count (CBC)
dc.subjectReactive oxygen species
dc.titleFeline obesity causes hematological and biochemical changes and oxidative stress – a pilot studyen
dc.typeArtigo
unesp.departmentGeografia - FCTEpt

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Ourinhos - FCTE - Faculdade de Ciências, Tecnologia e Educação