Non-aqueous Titration of Gatifloxacin in Pharmaceutical Formulations using Perchloric Acid
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Data
2003-10-01
Orientador
Coorientador
Pós-graduação
Curso de graduação
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Tipo
Artigo
Direito de acesso
Acesso aberto
Resumo
An inexpensive, simple, precise and rapid method for the determination of fluoroquinolone gatifloxacin in tablets is described. The procedure is based on the use of volumetric dosage in a non-aqueous medium in glacial acetic acid with 0.1 M perchloric acid. The method validation yielded good results and included the precision, recovery and accuracy. It was also found that the excipients in the commercial tablet preparation did not interfere with the assay.
Descrição
Palavras-chave
Fluoroquinolone , Gatifloxacin , Non-aqueous titration , Pharmaceutical analysis , acetic acid , crystal violet , excipient , gatifloxacin , perchloric acid , quinoline derived antiinfective agent , accuracy , analytic method , drug determination , drug formulation , quantitative assay , tablet , titrimetry , validation process , weight
Idioma
Inglês
Como citar
Acta Farmaceutica Bonaerense, v. 22, n. 4, p. 339-342, 2003.