Crystal structure of myotoxin-II: A myotoxic phospholipase A2 - Homologue from Bothrops moojeni venom.

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dc.contributor.authordeAzevedo, W. F.
dc.contributor.authorWard, R. J.
dc.contributor.authorLombardi, F. R.
dc.contributor.authorGiglio, JR
dc.contributor.authorSoares, A. M.
dc.contributor.authorFontes, MRM
dc.contributor.authorArni, R. K.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T15:19:46Z
dc.date.available2014-05-20T15:19:46Z
dc.date.issued1997-10-01
dc.description.abstractThe crystal structure of Myotoxin-II (MjTX-II), a Lys49 PLA(2)-homologue from Bothrops moojeni venom has been determined and refined at 2.0 Angstrom to a crystallographic residual of 19.7% (R-free = 28.1%). MjTX-II is a dimer in the crystal, with the monomers in the asymmetric unit related by a two-fold symmetry axis running through the dimer interface. The dimers of MjTX-II and the Lys49 PLA(2) from B. asper venom are similar, however the relative orientations of the monomers suggests a flexible dimer interface, which serves as a hinge between the two molecules.en
dc.description.affiliationUNIV NACL ESTADUAL SAO PAULO,IBIL,DEPT PHYS,BR-15054000 S JOSE RIO PR,SP,BRAZIL
dc.description.affiliationUNIV SAO PAULO,FMRP,DEPT BIOCHEM,BR-1449900 RIBEIRAO PRET,SP,BRAZIL
dc.description.affiliationUNIV ESTADUAL PAULISTA JULIO MESQUITA FILHO,DEPT BIOPHYS,BOTUCATU,SP,BRAZIL
dc.description.affiliationUnespUNIV ESTADUAL PAULISTA JULIO MESQUITA FILHO,DEPT BIOPHYS,BOTUCATU,SP,BRAZIL
dc.format.extent329-334
dc.identifier.citationProtein and Peptide Letters. Hilversum: Bentham Science Publ Bv, v. 4, n. 5, p. 329-334, 1997.
dc.identifier.issn0929-8665
dc.identifier.lattes9162508978945887
dc.identifier.orcid0000-0003-2460-1145
dc.identifier.urihttp://hdl.handle.net/11449/31154
dc.identifier.wosWOS:A1997YA77100007
dc.language.isoeng
dc.publisherBentham Science Publ Bv
dc.relation.ispartofProtein and Peptide Letters
dc.relation.ispartofjcr1.039
dc.relation.ispartofsjr0,429
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleCrystal structure of myotoxin-II: A myotoxic phospholipase A2 - Homologue from Bothrops moojeni venom.en
dc.typeArtigo
dcterms.licensehttp://eurekaselect.com/209
dcterms.rightsHolderBentham Science Publ Bv
unesp.author.lattes9162508978945887[7]
unesp.author.orcid0000-0003-2460-1145[7]

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