Association of CD44+/CD24-cells to more aggressive molecular phenotypes in canine mammary carcinomas

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dc.contributor.authorFigueroa, Fernanda Carmello [UNESP]
dc.contributor.authorZanetti, Juliana da Silva
dc.contributor.authorRibeiro-Silva, Alfredo
dc.contributor.authorFonseca-Alves, Carlos Eduardo [UNESP]
dc.contributor.authorRocha, Noeme Sousa [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-12-11T16:58:09Z
dc.date.available2018-12-11T16:58:09Z
dc.date.issued2015-01-01
dc.description.abstractLeading the cause of death among female dogs, mammary gland tumor awakes the interest of the scientific community, mostly because the similarities in clinical presentation and evolution to breast cancer in women. Due to the importance of investigating canine mammary tumors, this research aims to identify the protein expression of CD44, CD24, MUC-1, CD10 and ESA by immuno-histochemistry. Thus, slides were prepared by the tissue microarray technique to assess the presence of these markers in different subtypes. Of the 112 tumors, 66.9% were positive for CD10 (75/112), 42.86% positive for CD24 (48/112), 21.43% for ESA (24/112), 20.54% for MUC-1 (23/112) and 5.35% for CD44 (6/112). Of these tumors, 3.57% showed the immuno-phenotype CD44+/CD24-(4/112). The results suggest that mammary gland tumors of female dogs were positives for stem cell markers, which may be associated with cancer stem cells. This association also may allow setting further models to study breast cancer in women.en
dc.description.affiliationDepartment of Veterinary Clinic, School of Veterinary Medicine and Animal Science, Sao Paulo State University (UNESP)
dc.description.affiliationDepartment of Pathology and Forensic Medicine-Ribeirão Preto School of Medicine (FMRP), USP
dc.description.affiliationUnespDepartment of Veterinary Clinic, School of Veterinary Medicine and Animal Science, Sao Paulo State University (UNESP)
dc.format.extent119-127
dc.identifierhttp://dx.doi.org/10.3923/ijcr.2015.119.127
dc.identifier.citationInternational Journal of Cancer Research, v. 11, n. 3, p. 119-127, 2015.
dc.identifier.doi10.3923/ijcr.2015.119.127
dc.identifier.issn1811-9735
dc.identifier.issn1811-9727
dc.identifier.lattes
dc.identifier.orcid0000-0002-8188-8149
dc.identifier.scopus2-s2.0-84940036004
dc.identifier.urihttp://hdl.handle.net/11449/172017
dc.language.isoeng
dc.relation.ispartofInternational Journal of Cancer Research
dc.relation.ispartofsjr0,142
dc.relation.ispartofsjr0,142
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectCanine
dc.subjectMammary cancer
dc.subjectStem cells
dc.subjectTissue microarray
dc.titleAssociation of CD44+/CD24-cells to more aggressive molecular phenotypes in canine mammary carcinomasen
dc.typeArtigo
unesp.author.lattes6077735918469284
unesp.author.orcid0000-0002-8188-8149

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