Evaluation of Syngonanthus nitens (Bong.) Ruhl. extract as antifungal and in treatment of vulvovaginal candidiasis

dc.contributor.authorDe Freitas Araújo, Marcelo Gonzaga [UNESP]
dc.contributor.authorPacífico, Mariana
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorDos Santos, Lourdes Campaner
dc.contributor.authorIcely, Paula Alejandra
dc.contributor.authorMiró, Maria Soledad
dc.contributor.authorScarpa, Maria Virginia Costa [UNESP]
dc.contributor.authorBauab, Taís Maria [UNESP]
dc.contributor.authorSotomayor, Claudia Elena
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionChemistry Institute
dc.contributor.institutionNational University of Cordoba
dc.date.accessioned2014-05-27T11:30:49Z
dc.date.available2014-05-27T11:30:49Z
dc.date.issued2013-10-01
dc.description.abstractThe purpose of this study was to evaluate the in vitro anticandidal activity of a methanolic extract of Syngonanthus nitens scapes against different Candida species and clinical isolates from patients with vulvovaginal candidiasis (VVC), and its effect in vivo in the treatment of vaginal infection. Chemical characterization of the extract was performed by HPLC-UV analyses and showed the presence of flavones derivatives. The extract was effective against several Candida strains from our collection and species recovered from VVC patients, and was able to inhibit the yeast-hyphal transition. No cytotoxic activity against human female reproductive tract epithelial cells and no hemolytic activity against human red blood cells were observed. In the in vivo model of VVC, we evaluated the efficacy of the intravaginal treatment with a cream containing the extract at doses of 0.5, 1.0 and 2.0%. The treatment eradicated the vaginal fungal burden in infected rats after 8 days of treatment. S. nitens extract could be considered as an effective and non-toxic natural antifungal agent in the treatment of vulvovaginal candidiasis. © 2013 ISHAM.en
dc.description.affiliationBiological Sciences Department Faculty of Pharmaceutical Sciences São Paulo State University (UNESP), Araraquara, SP
dc.description.affiliationOrganic Chemistry Department Chemistry Institute, Araraquara, SP
dc.description.affiliationDrugs and Pharmaceuticals Department Faculty of Pharmaceutical Sciences São Paulo State University-UNESP, Araraquara, SP
dc.description.affiliationClinical Biochemistry Department Immunology, CIBICI-CONICET National University of Cordoba, Cordoba
dc.description.affiliationUnespBiological Sciences Department Faculty of Pharmaceutical Sciences São Paulo State University (UNESP), Araraquara, SP
dc.description.affiliationUnespDrugs and Pharmaceuticals Department Faculty of Pharmaceutical Sciences São Paulo State University-UNESP, Araraquara, SP
dc.format.extent673-682
dc.identifierhttp://dx.doi.org/10.3109/13693786.2013.795294
dc.identifier.citationMedical Mycology, v. 51, n. 7, p. 673-682, 2013.
dc.identifier.doi10.3109/13693786.2013.795294
dc.identifier.issn1369-3786
dc.identifier.issn1460-2709
dc.identifier.lattes4930795298045665
dc.identifier.lattes4910754838277580
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.scopus2-s2.0-84884330991
dc.identifier.urihttp://hdl.handle.net/11449/76768
dc.identifier.wosWOS:000324538900001
dc.language.isoeng
dc.relation.ispartofMedical Mycology
dc.relation.ispartofjcr2.799
dc.relation.ispartofsjr0,973
dc.relation.ispartofsjr0,973
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAnticandidal activity
dc.subjectSyngonanthus nitens
dc.subjectVulvovaginal candidiasis
dc.subjectYeast-hyphal transition
dc.subjectamphotericin B
dc.subjectantifungal agent
dc.subjectflavone derivative
dc.subjectflavonoid
dc.subjectplant extract
dc.subjectSyngonanthus nitens extract
dc.subjectunclassified drug
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectantifungal activity
dc.subjectantifungal susceptibility
dc.subjectCandida albicans
dc.subjectCandida krusei
dc.subjectCandida parapsilosis
dc.subjectCandida tropicalis
dc.subjectcell damage
dc.subjectcontrolled study
dc.subjectcream
dc.subjectdrug cytotoxicity
dc.subjectdrug efficacy
dc.subjectepithelium cell
dc.subjectEriocaulaceae
dc.subjecterythrocyte
dc.subjectevaluation
dc.subjectfemale
dc.subjectfemale genital system
dc.subjectfungus growth
dc.subjectgrowth inhibition
dc.subjecthemolysis
dc.subjecthigh performance liquid chromatography
dc.subjecthuman
dc.subjecthuman cell
dc.subjectin vitro study
dc.subjectminimum inhibitory concentration
dc.subjectnonhuman
dc.subjectrat
dc.subjectultraviolet spectroscopy
dc.subjectvagina candidiasis
dc.subjectvaginitis
dc.titleEvaluation of Syngonanthus nitens (Bong.) Ruhl. extract as antifungal and in treatment of vulvovaginal candidiasisen
dc.typeArtigo
dcterms.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
unesp.author.lattes4930795298045665
unesp.author.lattes4910754838277580
unesp.author.orcid0000-0003-3032-2556[3]
unesp.author.orcid0000-0001-6554-7689[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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