Advancing respiratory–cardiovascular physiology with the working heart–brainstem preparation over 25 years
dc.contributor.author | Paton, Julian F. R. | |
dc.contributor.author | Machado, Benedito H. | |
dc.contributor.author | Moraes, Davi J. A. | |
dc.contributor.author | Zoccal, Daniel B. [UNESP] | |
dc.contributor.author | Abdala, Ana P. | |
dc.contributor.author | Smith, Jeffrey C. | |
dc.contributor.author | Antunes, Vagner R. | |
dc.contributor.author | Murphy, David | |
dc.contributor.author | Dutschmann, Mathias | |
dc.contributor.author | Dhingra, Rishi R. | |
dc.contributor.author | McAllen, Robin | |
dc.contributor.author | Pickering, Anthony E. | |
dc.contributor.author | Wilson, Richard J. A. | |
dc.contributor.author | Day, Trevor A. | |
dc.contributor.author | Barioni, Nicole O. | |
dc.contributor.author | Allen, Andrew M. | |
dc.contributor.author | Menuet, Clément | |
dc.contributor.author | Donnelly, Joseph | |
dc.contributor.author | Felippe, Igor | |
dc.contributor.author | St-John, Walter M. | |
dc.contributor.institution | University of Auckland | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | |
dc.contributor.institution | University of Bristol | |
dc.contributor.institution | National Institutes of Health | |
dc.contributor.institution | University of Melbourne | |
dc.contributor.institution | University of Calgary | |
dc.contributor.institution | Mount Royal University | |
dc.contributor.institution | Aix-Marseille Université | |
dc.contributor.institution | Geisel School of Medicine at Dartmouth | |
dc.date.accessioned | 2023-03-01T20:36:05Z | |
dc.date.available | 2023-03-01T20:36:05Z | |
dc.date.issued | 2022-05-01 | |
dc.description.abstract | Twenty-five years ago, a new physiological preparation called the working heart–brainstem preparation (WHBP) was introduced with the claim it would provide a new platform allowing studies not possible before in cardiovascular, neuroendocrine, autonomic and respiratory research. Herein, we review some of the progress made with the WHBP, some advantages and disadvantages along with potential future applications, and provide photographs and technical drawings of all the customised equipment used for the preparation. Using mice or rats, the WHBP is an in situ experimental model that is perfused via an extracorporeal circuit benefitting from unprecedented surgical access, mechanical stability of the brain for whole cell recording and an uncompromised use of pharmacological agents akin to in vitro approaches. The preparation has revealed novel mechanistic insights into, for example, the generation of distinct respiratory rhythms, the neurogenesis of sympathetic activity, coupling between respiration and the heart and circulation, hypothalamic and spinal control mechanisms, and peripheral and central chemoreceptor mechanisms. Insights have been gleaned into diseases such as hypertension, heart failure and sleep apnoea. Findings from the in situ preparation have been ratified in conscious in vivo animals and when tested have translated to humans. We conclude by discussing potential future applications of the WHBP including two-photon imaging of peripheral and central nervous systems and adoption of pharmacogenetic tools that will improve our understanding of physiological mechanisms and reveal novel mechanisms that may guide new treatment strategies for cardiorespiratory diseases. | en |
dc.description.affiliation | Manaaki Manawa – The Centre for Heart Research Faculty of Medical & Health Science University of Auckland, Auckland | |
dc.description.affiliation | Department of Physiology School of Medicine of Ribeirão Preto University of São Paulo, São Paulo | |
dc.description.affiliation | Department of Physiology and Pathology School of Dentistry of Araraquara São Paulo State University, São Paulo | |
dc.description.affiliation | School of Physiology Pharmacology and Neuroscience Faculty of Biomedical Sciences University of Bristol | |
dc.description.affiliation | Cellular and Systems Neurobiology Section National Institute of Neurological Disorders and Stroke National Institutes of Health | |
dc.description.affiliation | Department of Physiology and Biophysics Institute of Biomedical Sciences University of São Paulo | |
dc.description.affiliation | Molecular Neuroendocrinology Research Group Bristol Medical School: Translational Health Sciences University of Bristol | |
dc.description.affiliation | Florey institute of Neuroscience and Mental Health University of Melbourne | |
dc.description.affiliation | Department of Physiology and Pharmacology Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute Cumming School of Medicine University of Calgary | |
dc.description.affiliation | Department of Biology Faculty of Science and Technology Mount Royal University | |
dc.description.affiliation | Department of Anatomy & Physiology University of Melbourne | |
dc.description.affiliation | Institut de Neurobiologie de la Méditerranée INMED UMR1249 INSERM Aix-Marseille Université | |
dc.description.affiliation | Department of Medicine Faculty of Medical and Health Sciences University of Auckland | |
dc.description.affiliation | Emeritus Department of Physiology and Neurobiology Geisel School of Medicine at Dartmouth | |
dc.description.affiliationUnesp | Department of Physiology and Pathology School of Dentistry of Araraquara São Paulo State University, São Paulo | |
dc.description.sponsorship | SIDS Calgary Society | |
dc.description.sponsorship | Health Research Council of New Zealand | |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
dc.description.sponsorship | Agence Nationale de la Recherche | |
dc.description.sponsorship | Australian Research Council | |
dc.description.sponsorship | British Heart Foundation | |
dc.description.sponsorship | National Institutes of Health | |
dc.description.sponsorshipId | Health Research Council of New Zealand: 19/687 | |
dc.description.sponsorshipId | CNPq: 313719/2020-9 | |
dc.description.sponsorshipId | CNPq: 437375/2018-8 | |
dc.description.sponsorshipId | Agence Nationale de la Recherche: ANR-21-CE14-0009-01 | |
dc.description.sponsorshipId | Australian Research Council: DP170104582 | |
dc.description.sponsorshipId | British Heart Foundation: Lectureship 1994 | |
dc.description.sponsorshipId | National Institutes of Health: U01 EB021960 | |
dc.format.extent | 2049-2075 | |
dc.identifier | http://dx.doi.org/10.1113/JP281953 | |
dc.identifier.citation | Journal of Physiology, v. 600, n. 9, p. 2049-2075, 2022. | |
dc.identifier.doi | 10.1113/JP281953 | |
dc.identifier.issn | 1469-7793 | |
dc.identifier.issn | 0022-3751 | |
dc.identifier.scopus | 2-s2.0-85128560751 | |
dc.identifier.uri | http://hdl.handle.net/11449/240863 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Physiology | |
dc.source | Scopus | |
dc.subject | cardiac ganglion | |
dc.subject | cardiac vagus | |
dc.subject | chemoreceptor | |
dc.subject | eupnoea | |
dc.subject | gasp | |
dc.subject | hypertension | |
dc.subject | hypoxia | |
dc.subject | Kölliker–Fuse | |
dc.subject | pre-Bötzinger complex | |
dc.subject | respiratory rhythm generation | |
dc.subject | sympathetic | |
dc.subject | sympathetic-respiratory coupling | |
dc.title | Advancing respiratory–cardiovascular physiology with the working heart–brainstem preparation over 25 years | en |
dc.type | Resenha | |
unesp.author.orcid | 0000-0001-7410-2913[1] | |
unesp.author.orcid | 0000-0001-5648-0929[2] | |
unesp.author.orcid | 0000-0001-6132-0217[3] | |
unesp.author.orcid | 0000-0002-0369-5907[4] | |
unesp.author.orcid | 0000-0001-6566-9205[5] | |
unesp.author.orcid | 0000-0002-6949-012X[7] | |
unesp.author.orcid | 0000-0002-4684-5215[10] | |
unesp.author.orcid | 0000-0003-0345-0456[12] | |
unesp.author.orcid | 0000-0001-9942-4775[13] | |
unesp.author.orcid | 0000-0001-7102-4235[14] | |
unesp.author.orcid | 0000-0002-2183-5360[16] | |
unesp.author.orcid | 0000-0002-7419-6427[17] | |
unesp.author.orcid | 0000-0002-6502-8069[18] | |
unesp.campus | Universidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquara | pt |
unesp.department | Fisiologia e Patologia - FOAR | pt |