New Insights into the Impact of Human Papillomavirus on Oral Cancer in Young Patients: Proteomic Approach Reveals a Novel Role for S100A8

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dc.contributor.authorMiranda-Galvis, Marisol
dc.contributor.authorCarneiro Soares, Carolina
dc.contributor.authorMoretto Carnielli, Carolina
dc.contributor.authorRamalho Buttura, Jaqueline
dc.contributor.authorSales de Sá, Raisa
dc.contributor.authorKaminagakura, Estela [UNESP]
dc.contributor.authorMarchi, Fabio Albuquerque
dc.contributor.authorPaes Leme, Adriana Franco
dc.contributor.authorLópes Pinto, Clóvis A.
dc.contributor.authorSantos-Silva, Alan Roger
dc.contributor.authorMoraes Castilho, Rogerio
dc.contributor.authorKowalski, Luiz Paulo
dc.contributor.authorSquarize, Cristiane Helena
dc.contributor.institutionUniversity of Michigan School of Dentistry
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversity of Vienna
dc.contributor.institutionBrazilian Center for Research in Energy and Materials (CNPEM)
dc.contributor.institutionA.C.Camargo Cancer Center (CIPE)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionCancer Institute of the State of São Paulo (ICESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionA.C.Camargo Cancer Center
dc.contributor.institutionUniversity of Michigan
dc.date.accessioned2023-07-29T14:01:46Z
dc.date.available2023-07-29T14:01:46Z
dc.date.issued2023-05-01
dc.description.abstractHuman papillomavirus (HPV) infection has recently been linked to a subset of cancers affecting the oral cavity. However, the molecular mechanisms underlying HPV-driven oral squamous cell carcinoma (OSCC) onset and progression are poorly understood. Methods: We performed MS-based proteomics profiling based on HPV status in OSCC in young patients, following biological characterization and cell assays to explore the proteome functional landscape. Results: Thirty-nine proteins are differentially abundant between HPV (+) and HPV (−) OSCC. Among them, COPS3, DYHC1, and S100A8 are unfavorable for tumor recurrence and survival, in contrast to A2M and Serpine1, low levels of which show an association with better DFS. Remarkably, S100A8 is considered an independent prognostic factor for lower survival rates, and at high levels, it alters tumor-associated immune profiling, showing a lower proportion of M1 macrophages and dendritic cells. HPV (+) OSCC also displayed the pathogen-associated patterns receptor that, when activated, triggered the S100A8 and NFκB inflammatory responses. Conclusion: HPV (+) OSCC has a peculiar microenvironment pattern distinctive from HPV (−), involving the expression of pathogen-associated pattern receptors, S100A8 overexpression, and NFκB activation and responses, which has important consequences in prognosis and may guide therapeutic decisions.en
dc.description.affiliationLaboratory of Epithelial Biology Department of Periodontics and Oral Medicine University of Michigan School of Dentistry
dc.description.affiliationOral Diagnosis Department Piracicaba Dental School University of Campinas (UNICAMP), SP
dc.description.affiliationDepartment of Microbiology Immune Biology and Genetics Center for Molecular Biology University of Vienna
dc.description.affiliationBrazilian Biosciences National Laboratory (LNBio) Brazilian Center for Research in Energy and Materials (CNPEM), SP
dc.description.affiliationLaboratory of Bioinformatics and Computational Biology A.C.Camargo Cancer Center (CIPE), SP
dc.description.affiliationDepartment of Bioscience and Oral Diagnosis Science and Technology Institute University of São Paulo State (UNESP), SP
dc.description.affiliationCenter for Translational Research in Oncology Cancer Institute of the State of São Paulo (ICESP), SP
dc.description.affiliationComprehensive Center for Precision Oncology University of São Paulo, SP
dc.description.affiliationDepartment of Anatomic Pathology A.C.Camargo Cancer Center, SP
dc.description.affiliationRogel Cancer Center University of Michigan
dc.description.affiliationHead and Neck Surgery Department Medical School University of São Paulo, SP
dc.description.affiliationDepartment of Head and Neck Surgery and Otorhinolaryngology A.C.Camargo Cancer Center, SP
dc.description.affiliationUnespDepartment of Bioscience and Oral Diagnosis Science and Technology Institute University of São Paulo State (UNESP), SP
dc.description.sponsorshipFaculty of Medicine, University of British Columbia
dc.identifierhttp://dx.doi.org/10.3390/cells12091323
dc.identifier.citationCells, v. 12, n. 9, 2023.
dc.identifier.doi10.3390/cells12091323
dc.identifier.issn2073-4409
dc.identifier.scopus2-s2.0-85159220696
dc.identifier.urihttp://hdl.handle.net/11449/249078
dc.language.isoeng
dc.relation.ispartofCells
dc.sourceScopus
dc.subjectHPV
dc.subjectoral cancer
dc.subjectprognosis
dc.subjectproteomics
dc.subjectS100A8
dc.titleNew Insights into the Impact of Human Papillomavirus on Oral Cancer in Young Patients: Proteomic Approach Reveals a Novel Role for S100A8en
dc.typeArtigo
unesp.author.orcid0000-0003-4798-584X[1]
unesp.author.orcid0000-0001-8336-7390[3]
unesp.author.orcid0000-0003-2456-4516[6]
unesp.author.orcid0000-0001-7959-147X[8]
unesp.author.orcid0000-0001-5358-612X[11]
unesp.author.orcid0000-0002-0481-156X[12]
unesp.author.orcid0000-0002-6782-3429[13]

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