GABA A but not GABA B receptors in the lateral hypothalamus modulate the tachycardic response to emotional stress in rats

Página do item simplificado
dc.contributor.authorGomes-de-Souza, Lucas [UNESP]
dc.contributor.authorBenini, Ricardo [UNESP]
dc.contributor.authorCosta-Ferreira, Willian [UNESP]
dc.contributor.authorCrestani, Carlos C. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-06T15:36:19Z
dc.date.available2019-10-06T15:36:19Z
dc.date.issued2019-05-01
dc.description.abstractThe lateral hypothalamus (LH) has been described as one of the hypothalamic areas involved in the behavioral and physiological responses triggered by aversive stimuli. Previous studies indicated involvement of the LH in cardiovascular responses to stress. Despite this evidence, the local neurochemical mechanisms involved in LH control of stress responses is still poorly understood. Therefore, in the present study, we investigated the role of GABAergic neurotransmission within the LH in cardiovascular responses induced by an acute session of restraint stress in rats. For this, we evaluated the effect of bilateral microinjection of selective antagonists of either GABA A or GABA B receptors into the LH on arterial pressure increase, heart rate (HR) increase and reduction in tail skin temperature induced by restraint stress. We found that microinjection of the selective GABA A receptor antagonist SR95531 into the LH decreased the increase in HR caused by restraint stress, but without affecting the increase in arterial pressure increase or the reduction in tail skin temperature. Conversely, LH treatment with the selective GABA B receptor antagonist CGP35348 did not affect the restraint-evoked cardiovascular changes. These findings indicate that GABAergic neurotransmission in the LH, acting through activation of local GABA A receptors, plays a facilitatory role in the tachycardic response observed during aversive threats.en
dc.description.affiliationLaboratory of Pharmacology School of Pharmaceutical Sciences São Paulo State University (UNESP), Rodovia Araraquara-Jau Km 01 (Campus Universitário), Campus Ville
dc.description.affiliationJoint UFSCar-UNESP Graduate Program in Physiological Sciences
dc.description.affiliationUnespLaboratory of Pharmacology School of Pharmaceutical Sciences São Paulo State University (UNESP), Rodovia Araraquara-Jau Km 01 (Campus Universitário), Campus Ville
dc.description.affiliationUnespJoint UFSCar-UNESP Graduate Program in Physiological Sciences
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipUniversidade Estadual Paulista
dc.description.sponsorshipIdFAPESP: 2015/05922-9
dc.description.sponsorshipIdFAPESP: 2017/19249-0
dc.description.sponsorshipIdCNPq: 456405/2014-3
dc.format.extent672-680
dc.identifierhttp://dx.doi.org/10.1016/j.euroneuro.2019.03.001
dc.identifier.citationEuropean Neuropsychopharmacology, v. 29, n. 5, p. 672-680, 2019.
dc.identifier.doi10.1016/j.euroneuro.2019.03.001
dc.identifier.issn1873-7862
dc.identifier.issn0924-977X
dc.identifier.scopus2-s2.0-85062704636
dc.identifier.urihttp://hdl.handle.net/11449/187445
dc.language.isoeng
dc.relation.ispartofEuropean Neuropsychopharmacology
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBlood pressure
dc.subjectGABAergic neurotransmission
dc.subjectHeart rate
dc.subjectHypothalamus
dc.subjectRestraint stress
dc.subjectSympathetic activity
dc.titleGABA A but not GABA B receptors in the lateral hypothalamus modulate the tachycardic response to emotional stress in ratsen
dc.typeArtigo
unesp.author.lattes1117432571971568[4]
unesp.author.orcid0000-0002-1942-858X[4]

Arquivos

Coleções

Artigos