The use of omega-3 fatty acids in the treatment of oral diseases

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dc.contributor.authorAzuma, Mariane Maffei
dc.contributor.authorCardoso, Carolina de Barros Morais [UNESP]
dc.contributor.authorda Silva, Cristiane Cantiga [UNESP]
dc.contributor.authorde Oliveira, Pedro Henrique Chaves [UNESP]
dc.contributor.authorJacinto, Rogério de Castilho [UNESP]
dc.contributor.authorAndrada, Ana Cristina
dc.contributor.authorCintra, Luciano Tavares Angelo [UNESP]
dc.contributor.institutionUniversity of Michigan
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity of Detroit Mercy School of Dentistry
dc.date.accessioned2021-06-25T10:37:13Z
dc.date.available2021-06-25T10:37:13Z
dc.date.issued2020-01-01
dc.description.abstractOmega-3 polyunsaturated fatty acids (ω-3 PUFAs) have been reported to exert important roles in the inflammatory response. There are many inflammatory diseases in dentistry which support the administration of ω-3 PUFAs as an adjunct therapy during the treatment of these diseases. The aim of this review was to evaluate the use of ω-3 PUFAs as an adjuvant therapy during the treatment of buccal diseases. The review showed that supplementation with ω-3 PUFAs was used for treatment of gingivitis, periodontal diseases, apical periodontitis, stomatitis, and orthodontic tooth movement. The results indicate that ω-3 PUFAs decreased the number of pro-inflammatory mediators in the gingival tissues of individuals with gingivitis and periodontitis. In apical periodontitis, the supplementation suppressed bone resorption and promoted bone formation in the periapical area of rats. During orthodontic movement, the supplementation showed a decrease of bone resorption in rats. It also showed that painful symptoms of recurrent aphthous stomatitis were alleviated in supplemented patients. In conclusion, the ω-3 PUFAs may be used as an adjuvant therapy in the treatment of inflammatory diseases that affect the oral cavity. However, more studies are required to elucidate the role of ω-3 PUFAs in decreasing oral cavity inflammatory processes.en
dc.description.affiliationDepartment of Cariology Restorative Sciences and Endodontics University of Michigan
dc.description.affiliationDepartment of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (Unesp)
dc.description.affiliationDivision of Endodontics University of Detroit Mercy School of Dentistry
dc.description.affiliationDental Assistance Center for Disabled Persons (CAOE) of the São Paulo State University (UNESP) School of Dentistry
dc.description.affiliationUnespDepartment of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (Unesp)
dc.description.affiliationUnespDental Assistance Center for Disabled Persons (CAOE) of the São Paulo State University (UNESP) School of Dentistry
dc.identifierhttp://dx.doi.org/10.1111/odi.13667
dc.identifier.citationOral Diseases.
dc.identifier.doi10.1111/odi.13667
dc.identifier.issn1601-0825
dc.identifier.issn1354-523X
dc.identifier.scopus2-s2.0-85093950542
dc.identifier.urihttp://hdl.handle.net/11449/206731
dc.language.isoeng
dc.relation.ispartofOral Diseases
dc.sourceScopus
dc.subjectaphthous stomatitis
dc.subjectgingivitis
dc.subjectomega-3 fatty acids
dc.subjectorthodontics
dc.subjectperiodontitis
dc.titleThe use of omega-3 fatty acids in the treatment of oral diseasesen
dc.typeResenha
unesp.author.orcid0000-0002-5196-514X[1]
unesp.author.orcid0000-0002-4943-7022[2]
unesp.author.orcid0000-0003-4313-7149[3]
unesp.author.orcid0000-0002-1593-7926[4]
unesp.author.orcid0000-0002-2362-8920[5]
unesp.author.orcid0000-0003-1782-1107[6]
unesp.author.orcid0000-0003-2348-7846[7]

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Araçatuba - CAOE - Centro de Assistência Odontológica a Excepcionais