Publicação:
Low-intensity laser therapy effect on the recovery of traumatic spinal cord injury

dc.contributor.authorPaula, Alecsandra Araujo
dc.contributor.authorNicolau, Renata Amadei
dc.contributor.authorLima, Mario de Oliveira
dc.contributor.authorCastillo Salgado, Miguel Angel [UNESP]
dc.contributor.authorCogo, Jose Carlos
dc.contributor.institutionUniv Vale Paraiba Univap
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-03-18T15:53:01Z
dc.date.available2015-03-18T15:53:01Z
dc.date.issued2014-11-01
dc.description.abstractScientific advances have been made to optimize the healing process in spinal cord injury. Studies have been developed to obtain effective treatments in controlling the secondary injury that occurs after spinal cord injury, which substantially changes the prognosis. Low-intensity laser therapy (LILT) has been applied in neuroscience due to its anti-inflammatory effects on biological tissue in the repairing process. Few studies have been made associating LILT to the spinal cord injury. The objective of this study was to investigate the effect of the LILT (GaAlAs laser-780 nm) on the locomotor functional recovery, histomorphometric, and histopathological changes of the spinal cord after moderate traumatic injury in rats (spinal cord injury at T9 and T10). Thirty-one adult Wistar rats were used, which were divided into seven groups: control without surgery (n = 3), control surgery (n = 3), laser 6 h after surgery (n = 5), laser 48 h after surgery (n = 5), medullar lesion (n = 5) without phototherapy, medullar lesion + laser 6 h after surgery (n = 5), and medullar lesion + laser 48 h after surgery (n = 5). The assessment of the motor function was performed using Basso, Beattie, and Bresnahan (BBB) scale and adapted Sciatic Functional Index (aSFI). The assessment of urinary dysfunction was clinically performed. After 21 days postoperative, the animals were euthanized for histological and histomorphometric analysis of the spinal cord. The results showed faster motor evolution in rats with spinal contusion treated with LILT, maintenance of the effectiveness of the urinary system, and preservation of nerve tissue in the lesion area, with a notorious inflammation control and increased number of nerve cells and connections. In conclusion, positive effects on spinal cord recovery after moderate traumatic spinal cord injury were shown after LILT.en
dc.description.affiliationUniv Vale Paraiba Univap, IP&D, BR-12244000 Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista UNESP, FOSJC, Sao Paulo, Brazil
dc.description.affiliationUniv Vale Paraiba Univap, Inst Res & Dev, BR-12244000 Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, FOSJC, Sao Paulo, Brazil
dc.format.extent1849-1859
dc.identifierhttp://dx.doi.org/10.1007/s10103-014-1586-4
dc.identifier.citationLasers In Medical Science. London: Springer London Ltd, v. 29, n. 6, p. 1849-1859, 2014.
dc.identifier.doi10.1007/s10103-014-1586-4
dc.identifier.issn0268-8921
dc.identifier.urihttp://hdl.handle.net/11449/116290
dc.identifier.wosWOS:000344539700011
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofLasers In Medical Science
dc.relation.ispartofjcr1.949
dc.relation.ispartofsjr0,713
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectLow-intensity laser therapyen
dc.subjectSpinal cord injuryen
dc.subjectNerve regenerationen
dc.titleLow-intensity laser therapy effect on the recovery of traumatic spinal cord injuryen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
dspace.entity.typePublication

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