Genetic heterogeneity of white markings in Quarter Horses

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dc.contributor.authorMaciel, S. V.S.A.
dc.contributor.authorde Queiroz, V. H.O.
dc.contributor.authorde Oliveira, C. A.A.
dc.contributor.authorde Godói, F. N.
dc.contributor.authorPereira, G. L. [UNESP]
dc.contributor.authorCuri, R. A. [UNESP]
dc.contributor.authorCosta, R. B.
dc.contributor.authorde Camargo, G. M.F.
dc.contributor.institutionUniversidade Federal da Bahia (UFBA)
dc.contributor.institutionUniversidade Federal Rural do Rio de Janeiro (UFRRJ)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2020-12-12T01:13:23Z
dc.date.available2020-12-12T01:13:23Z
dc.date.issued2020-02-01
dc.description.abstractWhite markings are very common in several horse breeds. These patterns are used for breed characterization, for the identification of animals (records) and might be associated with anomalies such as skin problems and deafness. The aim of the study was to perform genome-wide association analysis to identify genomic regions associated with the presence of white markings on the head and legs of Quarter Horses. The horses were from racing lineage and raised in Brazil. Records of 342 individuals and genotypes of 360 animals, genotyped for 63k, were used in a genome-wide association study, using the single-step procedure. Traits under analyses were presence of white markings on the head, forelegs, and hind legs. Few genomic regions influencing the traits were identified. Only one region containing the MC1R gene has been reported previously. The remaining genomic regions were detected for the first time in the present study. Within the genomic windows, some candidate genes were pointed out: ZEB2, KYNU, SLC36A1, STX12, MAP3K6, and GJB2. Markings in horses are characterized by genetic heterogeneity. It means that different genes can give origin to the same phenotype depending on the population. Candidate genes were, herein, described. It will permit future fine mapping studies in Quarter Horses in order to identify their causal mutations and also the development of molecular markers.en
dc.description.affiliationUniversidade Federal da Bahia (UFBA)
dc.description.affiliationUniversidade Federal Rural do Rio de Janeiro (UFRRJ)
dc.description.affiliationUniversidade Estadual Paulista (Unesp)
dc.description.affiliationUnespUniversidade Estadual Paulista (Unesp)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2014/20207-1
dc.identifierhttp://dx.doi.org/10.1016/j.livsci.2020.103935
dc.identifier.citationLivestock Science, v. 232.
dc.identifier.doi10.1016/j.livsci.2020.103935
dc.identifier.issn1871-1413
dc.identifier.scopus2-s2.0-85078542357
dc.identifier.urihttp://hdl.handle.net/11449/198455
dc.language.isoeng
dc.relation.ispartofLivestock Science
dc.sourceScopus
dc.subjectEquus caballus
dc.subjectHead
dc.subjectLegs
dc.subjectSNP
dc.subjectSpot
dc.titleGenetic heterogeneity of white markings in Quarter Horsesen
dc.typeArtigo

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