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Effects of the application of α1- and α2-adrenoceptor agonists and antagonists into the ventromedial hypothalamus on the sodium and potassium renal excretion

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dc.contributor.authorSaad, W. A.
dc.contributor.authorCamargo, L. A A
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-26T21:57:47Z
dc.date.available2014-05-26T21:57:47Z
dc.date.issued1984-01-01
dc.description.abstractThe effects of sodium and potassium excretion after intrahypothalamic administration of two α-adrenoceptor agonists and the effect of α-adrenoceptor antagonists were studied in groups of rats. Prazosin was equally effective at blocking the natriuretic and kaliuretic responses to the α1-adrenoceptor agonist phenylephrine and the mixed α1/α2-adrenoceptor agonist noradrenaline, while yohimbine which acts preferentially on α2-adrenoceptors was effective in potentiating these responses. These results suggest the presence of two types of α-adrenoceptors for the modulation of ventromedial hypothalamic pathways that interfere with the regulation of the two cations: stimulation of α1-adrenoceptors facilitates, while stimulation of α2-adrenoceptors inhibits the excretion of the ions.en
dc.format.extent228-234
dc.identifierhttp://dx.doi.org/10.1159/000137967
dc.identifier.citationPharmacology, v. 28, n. 4, p. 228-234, 1984.
dc.identifier.doi10.1159/000137967
dc.identifier.issn0031-7012
dc.identifier.scopus2-s2.0-0021362154
dc.identifier.urihttp://hdl.handle.net/11449/63648
dc.language.isoeng
dc.relation.ispartofPharmacology
dc.relation.ispartofjcr1.538
dc.relation.ispartofsjr0,502
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectalpha 1 adrenergic receptor
dc.subjectalpha 2 adrenergic receptor
dc.subjectalpha adrenergic receptor stimulating agent
dc.subjectnoradrenalin
dc.subjectphenylephrine
dc.subjectprazosin
dc.subjectyohimbine
dc.subjectanimal experiment
dc.subjectcentral nervous system
dc.subjectkidney
dc.subjectnonhuman
dc.subjectpotassium urine level
dc.subjectrat
dc.subjectsodium urine level
dc.subjectzona incerta
dc.subjectAdrenergic alpha-Agonists
dc.subjectAdrenergic alpha-Antagonists
dc.subjectAnimal
dc.subjectDogs
dc.subjectDose-Response Relationship, Drug
dc.subjectHypothalamus, Middle
dc.subjectNorepinephrine
dc.subjectPhenylephrine
dc.subjectPotassium
dc.subjectPrazosin
dc.subjectRabbits
dc.subjectRats
dc.subjectSodium
dc.subjectSupport, Non-U.S. Gov't
dc.subjectYohimbine
dc.titleEffects of the application of α1- and α2-adrenoceptor agonists and antagonists into the ventromedial hypothalamus on the sodium and potassium renal excretionen
dc.typeArtigo
dcterms.licensehttp://www.karger.com/Services/RightsPermissions
dspace.entity.typePublication

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