Publicação:
Parvalbumin and Ubiquitin as Potential Biomarkers of Mercury Contamination of Amazonian Brazilian Fish

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dc.contributor.authorVieira, José Cavalcante Souza [UNESP]
dc.contributor.authorde Oliveira, Grasieli [UNESP]
dc.contributor.authorBraga, Camila Pereira
dc.contributor.authorda Silva Fernandes, Mileni
dc.contributor.authorde Moraes, Paula Martin
dc.contributor.authorBuzalaf, Marília Afonso Rabelo
dc.contributor.authorde Oliveira, Lincoln Carlos Silva
dc.contributor.authorde Magalhães Padilha, Pedro [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Mato Grosso do Sul (UFMS)
dc.contributor.institutionUniversity of Nebraska
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionDom Bosco Catholic University (UCDB)
dc.date.accessioned2020-12-12T01:11:35Z
dc.date.available2020-12-12T01:11:35Z
dc.date.issued2020-10-01
dc.description.abstractRecent studies have demonstrated the association of mercury (Hg) with some fish proteins, milk, and hair from individuals exposed to the element in the Amazon. However, few studies involve identifying biomarkers of mercury exposure. Therefore, the present study aimed to identify potential biomarkers of Hg exposure in fish. For this, the muscular tissues of two species of fish (Prochilodus lineatus and Mylossoma duriventre) that feed the Amazonian human population were analyzed. Through the analyses obtained by graphite furnace atomic absorption spectrometry (GFAAS), it was possible to identify four protein SPOTS where mercury was present. These SPOTS, identified by mass spectrometry (ESI-MS/MS), included parvalbumin and ubiquitin-40S ribosomal protein S27a, and these being metalloproteins with biomarker characteristics. In addition, the results show the intense Hg/protein ratio observed in the two proteins, which makes metalloproteins strong candidates for biomarkers of mercury exposure. [Figure not available: see fulltext.].en
dc.description.affiliationSão Paulo State University (UNESP) Institute of Biosciences
dc.description.affiliationFederal University of Mato Grosso do Sul (UFMS)
dc.description.affiliationBiochemistry Department University of Nebraska
dc.description.affiliationUniversity of São Paulo (USP)
dc.description.affiliationLocal Development Dom Bosco Catholic University (UCDB)
dc.description.affiliationUnespSão Paulo State University (UNESP) Institute of Biosciences
dc.format.extent667-675
dc.identifierhttp://dx.doi.org/10.1007/s12011-020-02026-w
dc.identifier.citationBiological Trace Element Research, v. 197, n. 2, p. 667-675, 2020.
dc.identifier.doi10.1007/s12011-020-02026-w
dc.identifier.issn1559-0720
dc.identifier.issn0163-4984
dc.identifier.scopus2-s2.0-85077711774
dc.identifier.urihttp://hdl.handle.net/11449/198389
dc.language.isoeng
dc.relation.ispartofBiological Trace Element Research
dc.sourceScopus
dc.subjectBiomarkers
dc.subjectFish
dc.subjectMercury in the Amazon
dc.subjectMercury-bound proteins
dc.subjectMetalloproteins
dc.subjectProteomics
dc.titleParvalbumin and Ubiquitin as Potential Biomarkers of Mercury Contamination of Amazonian Brazilian Fishen
dc.typeArtigo
dspace.entity.typePublication
unesp.author.orcid0000-0001-7151-8403[1]

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