Mantle cell lymphoma involving the oral and maxillofacial region: a study of 20 cases

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dc.contributor.authorCarvalho, Marcus Vinícius Ribeiro
dc.contributor.authorRodrigues-Fernandes, Carla Isabelly
dc.contributor.authorde Cáceres, Cinthia Veronica Bardález López
dc.contributor.authorMesquita, Ricardo Alves
dc.contributor.authorMartins, Manoela Domingues
dc.contributor.authorRomán Tager, Elena María José
dc.contributor.authorCarlos, Roman
dc.contributor.authorPires, Fábio Ramôa
dc.contributor.authorRobinson, Liam
dc.contributor.authorvan Heerden, Willie F.P.
dc.contributor.authorValente, Vitor Bonetti [UNESP]
dc.contributor.authorXavier-Júnior, José Cândido Caldeira
dc.contributor.authorBernabé, Daniel Galera [UNESP]
dc.contributor.authorPontes, Hélder Antônio Rebelo
dc.contributor.authorSoares, Ciro Dantas
dc.contributor.authorda Costa, Mauro Henrique Melo
dc.contributor.authorVargas, Pablo Agustin
dc.contributor.authorFonseca, Felipe Paiva
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionFederal University of Rio Grande do Sul
dc.contributor.institutionCentro Clínico de Cabeza y Cuello/Hospital Herrera Llerandi
dc.contributor.institutionRio de Janeiro State University
dc.contributor.institutionUniversity of Pretoria
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionCentro Universitário Católico Unisalesiano Auxilium
dc.contributor.institutionUniversidade Federal do Pará (UFPA)
dc.contributor.institutionGetúlio Sales Diagnósticos
dc.contributor.institutionPrivate practice
dc.date.accessioned2023-07-29T13:23:28Z
dc.date.available2023-07-29T13:23:28Z
dc.date.issued2023-01-01
dc.description.abstractObjective: To investigate the clinicopathologic features of mantle cell lymphoma (MCL) involving the oral and maxillofacial region. Methods: The MCL cases were retrieved from the pathosis database of 6 pathology laboratories. Original hematoxylin and eosin slides and immunohistochemical reactions were reviewed for confirmation of the initial diagnosis. Clinical data of the cases were obtained from the patients’ pathosis and/or medical charts. Results: Twenty cases were included in the study, showing a male predominance and a mean age of 66 years. The oral cavity (12 cases) and the oropharynx (5 cases) were the most commonly involved subsites. Most cases presented as asymptomatic swellings, with 2 cases showing bilateral involvement of the palate. The classic histologic variant predominated (12/20 cases). All cases expressed CD20 with nuclear cyclin D1 positivity. SOX11 was seen in 9/13 cases, CD5 in 6/16 cases, Bcl2 in 16/19 cases, CD10 in 2/20 cases, and Bcl6 in 4/16 cases. Ki67 showed a mean proliferation index of 40.6%. The Epstein-Barr virus (EBV) was negative in all cases investigated. Follow-up data was available for 7 patients, with 5 currently alive and 2 deceased. Conclusion: Mantle cell lymphoma, albeit rare, may manifest in the oral and maxillofacial region. Its histologic heterogeneity demands a high degree of diagnostic skill from pathologists.en
dc.description.affiliationDepartment of Oral Diagnosis Piracicaba Dental School University of Campinas
dc.description.affiliationDepartment of Oral Surgery and Pathology School of Dentistry Universidade Federal de Minas Gerais
dc.description.affiliationDepartment of Oral Pathology School of Dentistry Federal University of Rio Grande do Sul
dc.description.affiliationPathology Section Centro Clínico de Cabeza y Cuello/Hospital Herrera Llerandi
dc.description.affiliationOral Pathology Dental School Rio de Janeiro State University
dc.description.affiliationDepartment of Oral Pathology and Oral Biology School of Dentistry Faculty of Health Sciences University of Pretoria
dc.description.affiliationOral Oncology Center São Paulo State University (UNESP) School of Dentistry
dc.description.affiliationPathology Institute of Araçatuba and School of Medicine Centro Universitário Católico Unisalesiano Auxilium
dc.description.affiliationOral Pathology Service João de Barros Barreto University Hospital Federal University of Pará
dc.description.affiliationGetúlio Sales Diagnósticos
dc.description.affiliationPrivate practice
dc.description.affiliationUnespOral Oncology Center São Paulo State University (UNESP) School of Dentistry
dc.format.extent101-109
dc.identifierhttp://dx.doi.org/10.1016/j.oooo.2022.08.018
dc.identifier.citationOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, v. 135, n. 1, p. 101-109, 2023.
dc.identifier.doi10.1016/j.oooo.2022.08.018
dc.identifier.issn2212-4403
dc.identifier.scopus2-s2.0-85139151394
dc.identifier.urihttp://hdl.handle.net/11449/247699
dc.language.isoeng
dc.relation.ispartofOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
dc.sourceScopus
dc.titleMantle cell lymphoma involving the oral and maxillofacial region: a study of 20 casesen
dc.typeArtigo
unesp.author.orcid0000-0002-9032-2067[3]

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Araçatuba - COB - Centro de Oncologia Bucal