SARS- CoV-2 infection and oxidative stress in early-onset preeclampsia

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dc.contributor.authorMarín, Reinaldo
dc.contributor.authorPujol, Flor H.
dc.contributor.authorRojas, Deliana
dc.contributor.authorSobrevia, Luis [UNESP]
dc.contributor.institutionVenezuelan Institute for Scientific Research (IVIC)
dc.contributor.institutionUniversidad de Sevilla
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversity of Queensland
dc.contributor.institutionUniversity Medical Center Groningen (UMCG)
dc.contributor.institutionPontificia Universidad Católica de Chile
dc.date.accessioned2022-04-28T19:48:23Z
dc.date.available2022-04-28T19:48:23Z
dc.date.issued2022-03-01
dc.description.abstractSARS-CoV-2 causes coronavirus disease 2019 (COVID-19) also in pregnant women. Infection in pregnancy leads to maternal and placental functional alterations. Pregnant women with vascular defects such as preeclampsia show high susceptibility to SARS-CoV-2 infection by undefined mechanisms. Pregnant women infected with SARS-CoV-2 show higher rates of preterm birth and caesarean delivery, and their placentas show signs of vasculopathy and inflammation. It is still unclear whether the foetus is affected by the maternal infection with this virus and whether maternal infection associates with postnatal affections. The SARS-CoV-2 infection causes oxidative stress and activation of the immune system leading to cytokine storm and next tissue damage as seen in the lung. The angiotensin-converting-enzyme 2 expression is determinant for these alterations in the lung. Since this enzyme is expressed in the human placenta, SARS-CoV-2 could infect the placenta tissue, although reported to be of low frequency compared with maternal lung tissue. Early-onset preeclampsia (eoPE) shows higher expression of ADAM17 (a disintegrin and metalloproteinase 17) causing an imbalanced renin-angiotensin system and endothelial dysfunction. A similar mechanism seems to potentially account for SARS-CoV-2 infection. This review highlights the potentially common characteristics of pregnant women with eoPE with those with COVID-19. A better understanding of the mechanisms of SARS-CoV-2 infection and its impact on the placenta function is determinant since eoPE/COVID-19 association may result in maternal metabolic alterations that might lead to a potential worsening of the foetal programming of diseases in the neonate, young, and adult.en
dc.description.affiliationLaboratory of Cell Bioenergetics Center for Biophysics and Biochemistry (CBB) Venezuelan Institute for Scientific Research (IVIC), AP 21827
dc.description.affiliationLaboratory of Molecular Virology Center for Microbiology and Cell Biology (CMCB) Venezuelan Institute for Scientific Research (IVIC), AP 21827
dc.description.affiliationDepartment of Physiology Faculty of Pharmacy Universidad de Sevilla
dc.description.affiliationMedical School (Faculty of Medicine) Sao Paulo State University (UNESP)
dc.description.affiliationUniversity of Queensland Centre for Clinical Research (UQCCR) Faculty of Medicine and Biomedical Sciences University of Queensland
dc.description.affiliationDepartment of Pathology and Medical Biology Division of Pathology University of Groningen University Medical Center Groningen (UMCG)
dc.description.affiliationCellular and Molecular Physiology Laboratory (CMPL) Department of Obstetrics Division of Obstetrics and Gynaecology School of Medicine Faculty of Medicine Pontificia Universidad Católica de Chile
dc.description.affiliationUnespMedical School (Faculty of Medicine) Sao Paulo State University (UNESP)
dc.description.sponsorshipMinisterio de Ciencia, Tecnología e Innovación Productiva
dc.description.sponsorshipPontificia Universidad Católica de Chile
dc.description.sponsorshipFondo Nacional de Desarrollo Científico y Tecnológico
dc.description.sponsorshipFondo Nacional de Ciencia Tecnología e Innovación
dc.description.sponsorshipIdFondo Nacional de Desarrollo Científico y Tecnológico: 1190316
dc.description.sponsorshipIdFondo Nacional de Ciencia Tecnología e Innovación: F-2005000222
dc.identifierhttp://dx.doi.org/10.1016/j.bbadis.2021.166321
dc.identifier.citationBiochimica et Biophysica Acta - Molecular Basis of Disease, v. 1868, n. 3, 2022.
dc.identifier.doi10.1016/j.bbadis.2021.166321
dc.identifier.issn1879-260X
dc.identifier.issn0925-4439
dc.identifier.scopus2-s2.0-85121227453
dc.identifier.urihttp://hdl.handle.net/11449/223061
dc.language.isoeng
dc.relation.ispartofBiochimica et Biophysica Acta - Molecular Basis of Disease
dc.sourceScopus
dc.subjectCOVID-19
dc.subjectHuman
dc.subjectPlacenta
dc.subjectPreeclampsia
dc.subjectPregnancy
dc.titleSARS- CoV-2 infection and oxidative stress in early-onset preeclampsiaen
dc.typeResenha

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