Hepatitis D infection in Brazil: Prevalence and geographical distribution of anti-Delta antibody

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dc.contributor.authorLago, Barbara V.
dc.contributor.authorMello, Francisco C. A.
dc.contributor.authorBarros, Tairine M.
dc.contributor.authorMello, Vinicius M.
dc.contributor.authorVillar, Livia M.
dc.contributor.authorLewis-Ximenez, Lia L.
dc.contributor.authorPardini, Maria Inês M. C. [UNESP]
dc.contributor.authorLampe, Elisabeth
dc.contributor.institutionFIOCRUZ
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T16:53:58Z
dc.date.available2018-12-11T16:53:58Z
dc.date.issued2018-08-01
dc.description.abstractIn Brazil, the Amazon Basin is endemic for hepatitis D virus (HDV) infection; however, studies in other regions of the country are scarce. This study aims to map the seroepidemiological situation of anti-Delta antibodies in chronic hepatitis B carriers in all five Brazilian geographic regions. Serum samples from 1240 HBsAg positive individuals (55.4% men; mean age 43.1 ± 13.4 years) from 24 of 26 Brazilian states were tested for the presence of anti-Delta antibodies using a commercial immunoassay. Anti-Delta antibodies were detected in 40 samples (3.2%; 52.5% female; mean age of 38.1 ± 13.8 years). Age less than 20 years was significantly associated with anti-HDV positivity (P < 0.001). The distribution of anti-Delta differed markedly in the diverse regions of the country. The highest prevalence of anti-HDV was found in the North (8.5%; P < 0.001), followed by Central West (2.5%), Southeast (1.7%), Northeast (0.8%), and South (0.0%). Anti-Delta antibodies were detected in 12 states, but more than 60% of the positive cases were observed in two states, Amazonas and Acre, located in the western portion of the Amazon region. The overall HDV prevalence of 3.2% emphasizes that HDV is far from being a disease under control in Brazil. Despite the low HDV prevalence in non-endemic regions, this infection persists as a major concern in two states (Acre and Amazonas) in the north of the country, indicating that a continuous epidemiological surveillance program should be implemented in all Brazilian regions.en
dc.description.affiliationLaboratório de Hepatites Virais Instituto Oswaldo Cruz FIOCRUZ
dc.description.affiliationInstituto de Tecnologia em Imunobiológicos (Bio-Manguinhos) FIOCRUZ
dc.description.affiliationLaboratório de Biologia Molecular Faculdade de Medicina (FMB) Divisão Hemocentro Universidade Estadual Paulista (Unesp) Campus de Botucatu
dc.description.affiliationUnespLaboratório de Biologia Molecular Faculdade de Medicina (FMB) Divisão Hemocentro Universidade Estadual Paulista (Unesp) Campus de Botucatu
dc.format.extent1358-1363
dc.identifierhttp://dx.doi.org/10.1002/jmv.25196
dc.identifier.citationJournal of Medical Virology, v. 90, n. 8, p. 1358-1363, 2018.
dc.identifier.doi10.1002/jmv.25196
dc.identifier.issn1096-9071
dc.identifier.issn0146-6615
dc.identifier.lattes4619588334582084
dc.identifier.scopus2-s2.0-85048727969
dc.identifier.urihttp://hdl.handle.net/11449/171117
dc.language.isoeng
dc.relation.ispartofJournal of Medical Virology
dc.relation.ispartofsjr0,978
dc.relation.ispartofsjr0,978
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectBrazil
dc.subjectHDV
dc.subjectseroepidemiology
dc.titleHepatitis D infection in Brazil: Prevalence and geographical distribution of anti-Delta antibodyen
dc.typeArtigo
unesp.author.lattes4619588334582084
unesp.author.orcid0000-0002-9173-6309[1]
unesp.author.orcid0000-0003-4561-4332[2]

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