Acute aerocystitis in Piaractus mesopotamicus: Participation of eicosanoids and pro-inflammatory cytokines

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dc.contributor.authorClaudiano, Gustavo da Silva [UNESP]
dc.contributor.authorPetrillo, Thalita R. [UNESP]
dc.contributor.authorManrique, Wilson G. [UNESP]
dc.contributor.authorCastro, Marcello P. [UNESP]
dc.contributor.authorLoureiro, Bruna A. [UNESP]
dc.contributor.authorMarcusso, Paulo F. [UNESP]
dc.contributor.authorBelo, Marco A.A. [UNESP]
dc.contributor.authorMoraes, Julieta R.E. [UNESP]
dc.contributor.authorDe Moraes, Flávio Ruas [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:29:01Z
dc.date.available2014-05-27T11:29:01Z
dc.date.issued2013-05-01
dc.description.abstractA total of 360 pacus (Piaractus mesopotamicus) were used to study vascular permeability (VP) and inflammatory cell component (CC) in induced aerocystitis in P. mesopotamicus through inoculation of inactivated Aeromonas hydrophila, and the effect of steroidal and nonsteroidal anti-inflammatory drugs. It was observed that after inoculation of A. hydrophila, the maximum VP occurred 180 min post-stimulus (MPS). Pretreatment with anti-inflammatory drugs inhibited VP, and the inhibitory effect of dexamethasone was seen earlier than the effects caused by meloxicam and indomethacin. Inoculation of the bacterium caused a gradual increase in the accumulation of cells, which reached a maximum 24 h post-stimulus (HPS). Pretreatment with dexamethasone, indomethacin and meloxicam reduced the accumulation of lymphocytes, thrombocytes, granulocytes and macrophages. There was no significant difference between the different doses of the drugs tested. The results suggest that eicosanoids and pro-inflammatory cytokines participate in chemical mediation in acute inflammation in pacus. © 2013 Elsevier Ltd.en
dc.description.affiliationDepartment of Veterinary Pathology School of Agrarian and Veterinary Sciences São Paulo State University (UNESP), Via Prof. Paulo Donato Castellane, km 05, Jaboticabal, SP 14884-900
dc.description.affiliationUnespDepartment of Veterinary Pathology School of Agrarian and Veterinary Sciences São Paulo State University (UNESP), Via Prof. Paulo Donato Castellane, km 05, Jaboticabal, SP 14884-900
dc.format.extent1057-1062
dc.identifierhttp://dx.doi.org/10.1016/j.fsi.2013.01.006
dc.identifier.citationFish and Shellfish Immunology, v. 34, n. 5, p. 1057-1062, 2013.
dc.identifier.doi10.1016/j.fsi.2013.01.006
dc.identifier.issn1050-4648
dc.identifier.issn1095-9947
dc.identifier.scopus2-s2.0-84875809339
dc.identifier.urihttp://hdl.handle.net/11449/75214
dc.identifier.wosWOS:000317870600005
dc.language.isoeng
dc.relation.ispartofFish and Shellfish Immunology
dc.relation.ispartofjcr3.185
dc.relation.ispartofsjr1,126
dc.relation.ispartofsjr1,126
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectChemical mediators
dc.subjectEvans blue
dc.subjectInflammation
dc.subjectTeleost
dc.subjectVascular alteration
dc.subjectantiinflammatory agent
dc.subjectbacterial vaccine
dc.subjectcytokine
dc.subjectdexamethasone
dc.subjecticosanoid
dc.subjectinactivated vaccine
dc.subjectindometacin
dc.subjectmeloxicam
dc.subjectthiazine derivative
dc.subjectthiazole derivative
dc.subjectAeromonas hydrophila
dc.subjectanimal
dc.subjectanimal disease
dc.subjectcapillary permeability
dc.subjectcell structure
dc.subjectCharacidae
dc.subjectdose response
dc.subjectGram negative infection
dc.subjectimmunology
dc.subjectmetabolism
dc.subjectmicrobiology
dc.subjecttime
dc.subjectAnimals
dc.subjectAnti-Inflammatory Agents
dc.subjectBacterial Vaccines
dc.subjectCapillary Permeability
dc.subjectCellular Structures
dc.subjectCytokines
dc.subjectDexamethasone
dc.subjectDose-Response Relationship, Drug
dc.subjectEicosanoids
dc.subjectGram-Negative Bacterial Infections
dc.subjectIndomethacin
dc.subjectThiazines
dc.subjectThiazoles
dc.subjectTime Factors
dc.subjectVaccines, Inactivated
dc.subjectBacteria (microorganisms)
dc.subjectPiaractus mesopotamicus
dc.subjectTeleostei
dc.titleAcute aerocystitis in Piaractus mesopotamicus: Participation of eicosanoids and pro-inflammatory cytokinesen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.orcid0000-0002-4163-6414[5]
unesp.author.orcid0000-0001-5845-3940[7]
unesp.author.orcid0000-0003-3097-3770[3]
unesp.author.orcid0000-0002-2677-4915[6]
unesp.author.orcid0000-0002-8384-8781[8]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt
unesp.departmentPatologia Veterinária - FCAVpt

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Jaboticabal - FCAV - Faculdade de Ciências Agrárias e Veterinárias