Evaluation of nanoparticles loaded with benzopsoralen in rat peritoneal exudate cells

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dc.contributor.authorGomes, A. J.
dc.contributor.authorFaustino, A. S.
dc.contributor.authorLunardi, C. N.
dc.contributor.authorLunardi, L. O.
dc.contributor.authorMachado, A. E. H.
dc.contributor.institutionUniversidade Federal de Uberlândia (UFU)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:22:52Z
dc.date.available2014-05-20T15:22:52Z
dc.date.issued2007-03-06
dc.description.abstractPsoralens are widely used for the treatment of hyperproliferative skin disease. In this work, we prepared nanoparticles (NP) containing a benzopsoralen (3-ethoxy carbonyl-2H-benzofuro[3,2-f]-1-benzopiran-2-one) by the solvent evaporation technique. We evaluated important NP parameters such as particle size, drug encapsulation efficiency, effect of the encapsulation process over the drug's photochemistry, zeta potential, external morphology, and in vitro release behavior. We also investigated the nanoparticle as a drug delivery system (DDS), as well as its target delivery to the action site, which is a very important parameter to increase the therapeutic use of psoralens and to reduce their side effects. The uptake of benzopsoralen-loaded PLGA nanoparticles by different kinds of cells found in rat peritoneal exudates was also studied. The photodamage promoted by irradiation with UV light revealed morphological characteristics of cell damage such as cytoplasmic vesiculation, mitochondrial damage, and swelling of both the granular endoplasmatic reticulum and nuclear membrane. This encapsulation method maintained the drug's properties and improved drug delivery to the target cell. (c) 2006 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de Uberlândia (UFU), Inst Quim, Lab Fotoquim, BR-38400089 Uberlandia, MG, Brazil
dc.description.affiliationUSP, Fac Ciências Farmaceut Ribeirao Preto, Farmacol Lab, BR-14040903 Ribeirao Preto, Brazil
dc.description.affiliationUniv Estadual Julio Mesquita Filho, Inst Biociencia, BR-13506900 Rio Claro, SP, Brazil
dc.description.affiliationUnespUniv Estadual Julio Mesquita Filho, Inst Biociencia, BR-13506900 Rio Claro, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.description.sponsorshipIdCNPq: 303911/2003-4
dc.description.sponsorshipIdCNPq: 302679/2002-2
dc.description.sponsorshipIdFAPEMIG: CEX 85/02
dc.format.extent153-160
dc.identifierhttp://dx.doi.org/10.1016/j.ijpharm.2006.09.035
dc.identifier.citationInternational Journal of Pharmaceutics. Amsterdam: Elsevier B.V., v. 332, n. 1-2, p. 153-160, 2007.
dc.identifier.doi10.1016/j.ijpharm.2006.09.035
dc.identifier.issn0378-5173
dc.identifier.urihttp://hdl.handle.net/11449/33778
dc.identifier.wosWOS:000244806500019
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofInternational Journal of Pharmaceutics
dc.relation.ispartofjcr3.862
dc.relation.ispartofsjr1,172
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectBenzopsoralenpt
dc.subjectExudates peritoneal cellpt
dc.subjectNanoparticlept
dc.subjectPUVApt
dc.titleEvaluation of nanoparticles loaded with benzopsoralen in rat peritoneal exudate cellsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.

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