Photomodulation multiple sessions as a promising preventive therapy for medication-related osteonecrosis of the jaws after tooth extraction in rats

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dc.contributor.authorStatkievicz, Cristian [UNESP]
dc.contributor.authorToro, Luan Felipe [UNESP]
dc.contributor.authorde Mello-Neto, João Martins [UNESP]
dc.contributor.authorde Sá, Daniela Pereira [UNESP]
dc.contributor.authorCasatti, Cláudio Aparecido [UNESP]
dc.contributor.authorIssa, João Paulo Mardegan
dc.contributor.authorCintra, Luciano Tavares Angelo [UNESP]
dc.contributor.authorde Almeida, Juliano Milanezi [UNESP]
dc.contributor.authorNagata, Maria José Hitomi [UNESP]
dc.contributor.authorGarcia, Valdir Gouveia [UNESP]
dc.contributor.authorTheodoro, Leticia Helena [UNESP]
dc.contributor.authorErvolino, Edilson [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-12-11T17:37:02Z
dc.date.available2018-12-11T17:37:02Z
dc.date.issued2018-07-01
dc.description.abstractThe aim of this study was to evaluate the effects of photobiomodulation (PBM) with multiple sessions of low-level laser on the alveolar repair process of rats with major risk factors for medication-related osteonecrosis of the jaws (MRONJ). Senile rats received 0.45 mL of vehicle (VEH and VEH-PBM) or 0.45 mL of 100 μg/kg zoledronate (ZOL and ZOL-PBM) administrated intraperitoneally every two days during seven weeks. After three weeks of initiation of drug treatment the first lower left molar was extracted. No local treatment was performed in VEH and ZOL. VEH-PBM and ZOL-PBM were submitted to laser irradiation (660 ± 10 nm; 0.035 W; 2.1 J; 60 s) on the extraction site at 0, 2 and 4 days postoperatively. Euthanasia was performed 28 days after tooth extraction. Histological sections of the hemimandible were submitted to histopathological and histomorphometric analysis, as well as to histochemistry for collagen fiber maturation and immunohistochemistry for pro-inflammatory cytokines. In ZOL, general impairment of tissue repair, areas with osteonecrosis, lower newly formed bone tissue (NFBT), smaller amount of mature collagen fibers and increased immunoreactivity for TNFα IL-1β and IL-6 were observed when compared to VEH and VEH-PBM. ZOL-PBM showed significant improvement in some parameters compared to ZOL, such as positive repair tissue, higher NFBT, greater amount of mature collagen fibers, besides TNFα and IL-1β immunoreactivity decrease. Zoledronate treatment severely compromised the tissue repair process of the tooth extraction site in rats with major risk factors for MRONJ. Based on parameters employed in the present study, PBM in multiple sessions can improve the alveolar repair process, constituting a promising preventive therapy to avoid the onset of post-extraction MRONJ.en
dc.description.affiliationGroup for the Research and Study of Laser in Dentistry School of Dentistry of Araçatuba São Paulo State University (UNESP)
dc.description.affiliationDepartment of Surgery and Integrated Clinic School of Dentistry São Paulo State University (UNESP), Rua José Bonifácio, 1193, CEP
dc.description.affiliationDepartment of Basic Science School of Dentistry São Paulo State University (UNESP), Rua José Bonifácio, 1193, CEP
dc.description.affiliationInstitute of Biosciences São Paulo State University (UNESP), Rua Prof. Dr. Antônio Celso Wagner Zanin, 250, CEP
dc.description.affiliationDepartment of Morphology Physiology and Basic Pathology School of Dentistry São Paulo University (USP), Avenida do Café s/n, CEP
dc.description.affiliationDepartment of Restorative Dentistry School of Dentistry São Paulo StateUniversity (UNESP), Rua José Bonifácio, 1193, CEP
dc.description.affiliationUnespGroup for the Research and Study of Laser in Dentistry School of Dentistry of Araçatuba São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Surgery and Integrated Clinic School of Dentistry São Paulo State University (UNESP), Rua José Bonifácio, 1193, CEP
dc.description.affiliationUnespDepartment of Basic Science School of Dentistry São Paulo State University (UNESP), Rua José Bonifácio, 1193, CEP
dc.description.affiliationUnespInstitute of Biosciences São Paulo State University (UNESP), Rua Prof. Dr. Antônio Celso Wagner Zanin, 250, CEP
dc.description.affiliationUnespDepartment of Restorative Dentistry School of Dentistry São Paulo StateUniversity (UNESP), Rua José Bonifácio, 1193, CEP
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: #2012/03067-6
dc.description.sponsorshipIdFAPESP: #2013/26779-4
dc.description.sponsorshipIdFAPESP: #2014/02199-1
dc.description.sponsorshipIdFAPESP: #2014/14118-6
dc.description.sponsorshipIdCNPq: #28040-2013
dc.description.sponsorshipIdCNPq: #30699-2014
dc.format.extent7-17
dc.identifierhttp://dx.doi.org/10.1016/j.jphotobiol.2018.05.004
dc.identifier.citationJournal of Photochemistry and Photobiology B: Biology, v. 184, p. 7-17.
dc.identifier.doi10.1016/j.jphotobiol.2018.05.004
dc.identifier.file2-s2.0-85046880648.pdf
dc.identifier.issn1873-2682
dc.identifier.issn1011-1344
dc.identifier.lattes4408095517346846
dc.identifier.lattes9235743081667362
dc.identifier.lattes8399870097572073
dc.identifier.lattes8487462626931877
dc.identifier.orcid0000-0003-4859-0583
dc.identifier.orcid0000-0001-5650-7343
dc.identifier.scopus2-s2.0-85046880648
dc.identifier.urihttp://hdl.handle.net/11449/179857
dc.language.isoeng
dc.relation.ispartofJournal of Photochemistry and Photobiology B: Biology
dc.relation.ispartofsjr0,698
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBisphosphonates
dc.subjectJaw
dc.subjectLow-level laser therapy
dc.subjectOsteonecrosis
dc.subjectPhotobiomodulation
dc.titlePhotomodulation multiple sessions as a promising preventive therapy for medication-related osteonecrosis of the jaws after tooth extraction in ratsen
dc.typeArtigo
unesp.author.lattes4408095517346846[12]
unesp.author.lattes9235743081667362
unesp.author.lattes8399870097572073
unesp.author.lattes8487462626931877[5]
unesp.author.orcid0000-0002-2025-7108 0000-0002-2025-7108[4]
unesp.author.orcid0000-0003-4859-0583[2]
unesp.author.orcid0000-0001-5650-7343[5]

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Artigos - Ciências Básicas - FOA
Artigos - Cirurgia e Clínica Integrada - FOA
Artigos - Odontologia Restauradora - FOA