Efeitos da exposição subcrônica à sibutramina sobre parâmetros reprodutivos e fertilidade de ratos machos wistar adultos

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dc.contributor.advisorKempinas, Wilma De Grava [UNESP]
dc.contributor.authorMissassi, Gabriela [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2021-03-10T12:58:37Z
dc.date.available2021-03-10T12:58:37Z
dc.date.issued2016
dc.description.abstractSibutramine is a non-selective serotonin-norepinephrine reuptake inhibitor largely used for weight loss. In a previous work, we showed the pharmacological mechanisms involved in the reduction on sperm quality and fertility of rats exposed to this anorexigen in the light phase of light-dark (l/d) cycle. Considering that rodents are nightlife animals, with higher metabolic activity during the dark phase, the present work aimed to further investigate whether the alterations found in rat sperm quality would be maintained after treatment in this period. For this, adult male Wistar rats were treated with sibutramine (10 mg/kg/day) or vehicle for 15 days in the dark phase of the light-dark cycle. Sibutramine decreased final body and reproductive organ weights, as well as the testosterone levels and number of sperm with progressive motility. These animals also had an acceleration in the sperm transit time in the epididymis and a decrease in sperm concentrations throughout this organ (histopathological analysis). In conclusion, the impairment of reproductive parameters were enhanced when the exposure occurred during the dark phase of the l/d cycle, which corresponds to more active period of these animals.en
dc.description.abstractNão disponívelpt
dc.format.extent[28] f.
dc.identifier.aleph990008983700206341
dc.identifier.citationMISSASSI, Gabriela. Efeitos da exposição subcrônica à sibutramina sobre parâmetros reprodutivos e fertilidade de ratos machos wistar adultos. 2016. 1 CD-ROM. Trabalho de conclusão de curso (bacharelado - Ciencias Biológicas) - Universidade Estadual Paulista Júlio de Mesquita Filho, Instituto de Biociências de Botucatu, 2016.
dc.identifier.filehttp://www.athena.biblioteca.unesp.br/exlibris/bd/capelo/2019-01-28/000898370.pdf
dc.identifier.urihttp://hdl.handle.net/11449/203873
dc.language.isopor
dc.publisherUniversidade Estadual Paulista (Unesp)
dc.rights.accessRightsAcesso aberto
dc.sourceAlma
dc.subjectToxicidade - Testespt
dc.subjectEpidídimopt
dc.subjectSibutraminapt
dc.subjectDrogas - Efeito fisiológicopt
dc.subjectSêmenpt
dc.subjectRato como animal de laboratoriopt
dc.subjectEpididymisen
dc.titleEfeitos da exposição subcrônica à sibutramina sobre parâmetros reprodutivos e fertilidade de ratos machos wistar adultospt
dc.title.alternativeEffects of subchronic exposure to sibutramine on reproductive parameters and fertility of wistar adult male ratsen
dc.typeTrabalho de conclusão de curso
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.undergraduateCiências Biológicas - IBBpt

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