Cell wall fractions from Paracoccidioides brasiliensis induce hypergammaglobulinemia

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Oliveira, Silvio Luis de [UNESP]
Silva, Marcelo Fernandes da [UNESP]
Soares, Angela Maria Victoriano de Campos [UNESP]
Silva, Celio Lopes

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The antibody response against the antigen sheep red blood cells (SRBC) was investigated in mice pre-treated with formalin-killed Paracoccidioides brasiliensis or with cell wall fractions of the fungus. Pre-treatment with P. brasiliensis, as well as with the F1 fraction and beta-glucan significantly increased the anti-SRBC antibody response in the experimental groups as compared to the control group that received only SRBC. This immunomodulatory effect varied with the different doses employed and with pre-treatment time. We conclude that the cell wall fractions of P. brasiliensis might play an important role in the hypergammaglobulinemia associated with Paracoccidioidomycosis. © 1993 Kluwer Academic Publishers.



Beta-glucan, Cell wall, Hypergammaglobulinemia, Paracoccidioides brasiliensis, Paracoccidioidomycosis

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Mycopathologia, v. 121, n. 1, p. 1-5, 1993.