In vitro and in vivo acaricide action of juvenoid analogs produced from the chemical modification of Cymbopogon spp. and Corymbia citriodora essential oil on the cattle tick Rhipicephalus (Boophilus) microplus

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dc.contributor.authorChagas, Ana Carolina S.
dc.contributor.authorDomingues, Luciana Ferreira [UNESP]
dc.contributor.authorFantatto, Rafaela R.
dc.contributor.authorGiglioti, Rodrigo [UNESP]
dc.contributor.authorOliveira, Marcia C. S.
dc.contributor.authorOliveira, Dariiela H.
dc.contributor.authorMano, Renata A.
dc.contributor.authorJacob, Raquel G.
dc.contributor.institutionEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionCtr Univ Cent Paulista
dc.contributor.institutionUniv Fed Pelotas
dc.date.accessioned2015-03-18T15:54:08Z
dc.date.available2015-03-18T15:54:08Z
dc.date.issued2014-09-15
dc.description.abstractThe present study aimed to evaluate the acaricidal action of the chemically modified essential oil of Cymbopogon spp. and Corymbia citriodora on Rhipicephalus (Boophilus) microplus. Citronellal was converted into N-butylcitronellylamine and in N-prop-2-inylcitronellylamine, analogs of juvenoids, by reductive amination using butylamine (N1 to N3) and propargylamine (N4 to N7). In vitro assays included the adult immersion, and larval packet tests. Engorged females were weighed in groups of 10 and tested in three replicates for six concentrations. They were immersed in the modified oils or control solution and incubated. In the larval packet test, the same substances and concentrations were evaluated in three replicates. In the in vivo test, six pastured heifers naturally infested with R. (B.) microplus were used per treatment: negative control, positive control (amitraz, Triatox (R)), original oil of C citriodora at 1.5%, and modified oil containing 0.9% N-prop-2-inylcitronellylamine (N7). Ticks were counted in the right side of the body in 24 animals from day D-3 to D21. LC50 and LC90 were obtained by Probit analysis, while the in vivo results were log transformed and compared using the Tukey test. Among the nitrocellylamines tested in vitro, N6 was most effective on the engorged females (100% efficacy at 50 mg/mL) and N7 on the larvae (100% efficacy at 6.25 mg/mL). In the test with larvae, the original oil of C. citriodora was less effective than the counterpart modified oil (N7), proving that the chemical modification optimized its effect. In the in vivo test, no significant difference was observed between N7 and the negative control. The average numbers of ticks on the animals' right side were 32.8, 8.1,37.9 and 35.4 for the negative control, positive control, original oil and N7, respectively. The chemical modification improved the efficacy in vitro, but it was not observed in vivo, perhaps due to the low stability of the amines under field conditions. The evaluation carried out here has not been previously studied, so this concept expands the horizon for research into chemically modified substances for parasite control and shed light on the challenges to find effective formulations and application methods. (C) 2014 Elsevier B.V. All rights reserved.en
dc.description.affiliationEmbrapa Pecuaria Sudeste, Lab Sanidade Anim, BR-13560970 Sao Carlos, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Programa Pos Grad, Jaboticabal, SP, Brazil
dc.description.affiliationCtr Univ Cent Paulista, Sao Carlos, SP, Brazil
dc.description.affiliationUniv Fed Pelotas, Lab Sintese Orgtin Limpa, Pelotas, RS, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Programa Pos Grad, Jaboticabal, SP, Brazil
dc.description.sponsorshipEmpresa Brasileira de Pesquisa Agropecuaria (Embrapa)
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdEmpresa Brasileira de Pesquisa Agropecuaria (Embrapa)03.11.01.023.00.00
dc.description.sponsorshipIdFundacao de Amparo a Pesquisa do Estado do Rio Grande do SulFAPERG/PRONEX 10/0005-1
dc.description.sponsorshipIdFundacao de Amparo a Pesquisa do Estado do Rio Grande do SulPRONEM 11/2026-4
dc.description.sponsorshipIdCNPq: 310596/2010-6
dc.format.extent277-284
dc.identifierhttp://dx.doi.org/10.1016/j.vetpar.2014.06.030
dc.identifier.citationVeterinary Parasitology. Amsterdam: Elsevier Science Bv, v. 205, n. 1-2, p. 277-284, 2014.
dc.identifier.doi10.1016/j.vetpar.2014.06.030
dc.identifier.issn0304-4017
dc.identifier.urihttp://hdl.handle.net/11449/116792
dc.identifier.wosWOS:000342548000038
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofVeterinary Parasitology
dc.relation.ispartofjcr2.422
dc.relation.ispartofsjr1,275
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectBotanical acaricidesen
dc.subjectPhytotherapyen
dc.subjectJuvenoidsen
dc.subjectCitronellylaminesen
dc.subjectCitronellalen
dc.subjectRhipicephalus (Boophilus) microplusen
dc.titleIn vitro and in vivo acaricide action of juvenoid analogs produced from the chemical modification of Cymbopogon spp. and Corymbia citriodora essential oil on the cattle tick Rhipicephalus (Boophilus) microplusen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0002-1700-0547[4]
unesp.author.orcid0000-0003-3939-0088[1]
unesp.author.orcid0000-0002-7038-4607[6]

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