Immunohistochemical and morphometric evaluation of gastrocnemius muscle and myotendinous junction of golden retriever dogs with muscular dystrophy

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dc.contributor.authorBeretta, Daniel Côrtes
dc.contributor.authorMoraes, Julieta Rodini Engracia [UNESP]
dc.contributor.authorEngracia Filho, Jair Rodini [UNESP]
dc.contributor.authorMouri Malvestio, Lygia Maria [UNESP]
dc.contributor.authorMoraes, Flávio Ruas [UNESP]
dc.contributor.institutionRio Verde University (FESURV)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-29T07:20:24Z
dc.date.available2022-04-29T07:20:24Z
dc.date.issued2014-01-01
dc.description.abstractIn this research we studied the alterations in the muscles and myotendinous junction of dogs with muscular dystrophy. Gastrocnemius muscle (GM) and myotendinous junction (MTJ) samples of 3 controls and 6 dystrophic dogs were subjected to histopathological and immunohistochemical assays. Histopathological/histomorphometric analysis showed that the lesions in the GM were more pronounced and showed the highest percentage of Fiber Type II (FTII) and low values for the minimum diameters and areas of Fiber Type I (FTI) and FTII than those in the MTJ. FTII in dystrophic MTJ was morphologically similar to the controls. There was a significant difference (p < 0.07) in the MHCI antigen compared to the control. We conclude that the preservation of the morphological features of the MTJ can be directly related to a better stabilization of FTII, lower expression of the MHCI complex and less cytotoxic activity of CD8.en
dc.description.affiliationRio Verde University (FESURV)
dc.description.affiliationDepartment of Veterinary Pathology, São Paulo State University, Jaboticabal, São Paulo
dc.description.affiliationUnespDepartment of Veterinary Pathology, São Paulo State University, Jaboticabal, São Paulo
dc.format.extent70-81
dc.identifier.citationBrazilian Journal of Veterinary Pathology, v. 7, n. 2, p. 70-81, 2014.
dc.identifier.issn1983-0246
dc.identifier.scopus2-s2.0-84905264896
dc.identifier.urihttp://hdl.handle.net/11449/227839
dc.language.isoeng
dc.relation.ispartofBrazilian Journal of Veterinary Pathology
dc.sourceScopus
dc.subjectCanine muscular dystrophy
dc.subjectDogs
dc.subjectDuchenne muscular dystrophy
dc.subjectImmunohistochemistry
dc.subjectMiopathy
dc.titleImmunohistochemical and morphometric evaluation of gastrocnemius muscle and myotendinous junction of golden retriever dogs with muscular dystrophyen
dc.typeArtigo

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