Combined effects of curcumin and lycopene or bixin in yoghurt on inhibition of LDL oxidation and increases in HDL and paraoxonase levels in streptozotocin-diabetic rats

Assis, Renata Pires [UNESP]; Arcaro, Carlos Alberto [UNESP]; Gutierres, Vânia Ortega [UNESP]; Oliveira, Juliana Oriel [UNESP]; Costa, Paulo Inácio [UNESP]; Baviera, Amanda Martins [UNESP]; Brunetti, Iguatemy Lourenço [UNESP]

Combined effects of curcumin and lycopene or bixin in yoghurt on inhibition of LDL oxidation and increases in HDL and paraoxonase levels in streptozotocin-diabetic rats

Arquivos

2-s2.0-85016097819.pdf (1.51 MB)

Data

2017-04-01

Autores

Assis, Renata Pires

Arcaro, Carlos Alberto

Gutierres, Vânia Ortega

Oliveira, Juliana Oriel

Costa, Paulo Inácio

Baviera, Amanda Martins

Brunetti, Iguatemy Lourenço

Tipo

Artigo

Direito de acesso

Acesso aberto

Resumo

Combination therapy using natural antioxidants to manage diabetes mellitus and its complications is an emerging trend. The aim of this study was to investigate the changes promoted by treatment of streptozotocin (STZ)-diabetic rats with yoghurt enriched with the bioactives curcumin, lycopene, or bixin (the latter two being carotenoids). Antioxidants were administered individually, or as mixtures, and biomarkers of metabolic and oxidative disturbances, particularly those associated with cardiovascular risk, were assessed. Treatment of STZ-diabetic rats with natural products individually decreased glycemia, triacylglycerol, total-cholesterol, oxidative stress biomarkers, including oxidized low-density lipoprotein (ox-LDL), and increased the activities of antioxidant enzymes. Individual carotenoids increased both high-density lipoprotein (HDL) and paraoxonase levels, whereas curcumin increased only paraoxonase. Treatments with mixtures of curcumin and lycopene or bixin had combined effects, decreasing biomarkers of carbohydrate and lipid disturbances (curcumin effect), increasing the HDL levels (carotenoids effects) and mitigating oxidative stress (curcumin and carotenoids effects). The combined effects also led to prevention of the LDL oxidation, thereby mitigating the cardiovascular risk in diabetes. These findings provide evidence for the beneficial effect of curcumin and carotenoid mixtures as a supplementation having antioxidant and antiatherogenic potentials, thus appearing as an interesting strategy to be studied as a complementary therapy for diabetic complications.