Combined effects of curcumin and lycopene or bixin in yoghurt on inhibition of LDL oxidation and increases in HDL and paraoxonase levels in streptozotocin-diabetic rats

dc.contributor.authorAssis, Renata Pires [UNESP]
dc.contributor.authorArcaro, Carlos Alberto [UNESP]
dc.contributor.authorGutierres, Vânia Ortega [UNESP]
dc.contributor.authorOliveira, Juliana Oriel [UNESP]
dc.contributor.authorCosta, Paulo Inácio [UNESP]
dc.contributor.authorBaviera, Amanda Martins [UNESP]
dc.contributor.authorBrunetti, Iguatemy Lourenço [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:10:49Z
dc.date.available2018-12-11T17:10:49Z
dc.date.issued2017-04-01
dc.description.abstractCombination therapy using natural antioxidants to manage diabetes mellitus and its complications is an emerging trend. The aim of this study was to investigate the changes promoted by treatment of streptozotocin (STZ)-diabetic rats with yoghurt enriched with the bioactives curcumin, lycopene, or bixin (the latter two being carotenoids). Antioxidants were administered individually, or as mixtures, and biomarkers of metabolic and oxidative disturbances, particularly those associated with cardiovascular risk, were assessed. Treatment of STZ-diabetic rats with natural products individually decreased glycemia, triacylglycerol, total-cholesterol, oxidative stress biomarkers, including oxidized low-density lipoprotein (ox-LDL), and increased the activities of antioxidant enzymes. Individual carotenoids increased both high-density lipoprotein (HDL) and paraoxonase levels, whereas curcumin increased only paraoxonase. Treatments with mixtures of curcumin and lycopene or bixin had combined effects, decreasing biomarkers of carbohydrate and lipid disturbances (curcumin effect), increasing the HDL levels (carotenoids effects) and mitigating oxidative stress (curcumin and carotenoids effects). The combined effects also led to prevention of the LDL oxidation, thereby mitigating the cardiovascular risk in diabetes. These findings provide evidence for the beneficial effect of curcumin and carotenoid mixtures as a supplementation having antioxidant and antiatherogenic potentials, thus appearing as an interesting strategy to be studied as a complementary therapy for diabetic complications.en
dc.description.affiliationDepartment of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University-UNESP
dc.description.affiliationUnespDepartment of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University-UNESP
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCNPq: 141998/2012-1
dc.description.sponsorshipIdFAPESP: 1998/09152-6
dc.identifierhttp://dx.doi.org/10.3390/ijms18040332
dc.identifier.citationInternational Journal of Molecular Sciences, v. 18, n. 4, 2017.
dc.identifier.doi10.3390/ijms18040332
dc.identifier.file2-s2.0-85016097819.pdf
dc.identifier.issn1422-0067
dc.identifier.issn1661-6596
dc.identifier.scopus2-s2.0-85016097819
dc.identifier.urihttp://hdl.handle.net/11449/174374
dc.language.isoeng
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.relation.ispartofsjr1,260
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBixin
dc.subjectCardiovascular risk
dc.subjectCurcumin
dc.subjectDiabetes mellitus
dc.subjectLycopene
dc.subjectOxidative stress
dc.titleCombined effects of curcumin and lycopene or bixin in yoghurt on inhibition of LDL oxidation and increases in HDL and paraoxonase levels in streptozotocin-diabetic ratsen
dc.typeArtigo
unesp.author.lattes3736475025187750[6]
unesp.author.orcid0000-0003-0987-5295[6]

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