Role of stressful and traumatic life events in obsessive-compulsive disorder

dc.contributor.authorFontenelle, Leonardo F.
dc.contributor.authorCocchi, Luca
dc.contributor.authorHarrison, Ben J.
dc.contributor.authorMiguel, Euripedes C.
dc.contributor.authorTorres, Albina Rodrigues [UNESP]
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionUniversidade Federal Fluminense (UFF)
dc.contributor.institutionUniversity of Melbourne and Melbourne Health
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:25:28Z
dc.date.available2014-05-27T11:25:28Z
dc.date.issued2011-02-01
dc.description.abstractWhilst genetic factors are thought to contribute to the development of obsessive-compulsive disorder (OCD), the role of environmental factors in OCD is only beginning to be understood. In this article, we review the influence of stress-related factors in OCD. Overall, studies indicate that: patients with OCD frequently report stressful and traumatic life events before illness onset, although these rates do not seem to be significantly different from those described in other disorders; the association between OCD and post-traumatic stress disorder (PTSD) might result from symptom overlap, although cases of patients developing OCD after PTSD and showing obsessive-compulsive symptoms that were unrelated to trauma have been described fairly consistently; it is unclear whether patients with OCD and a history of stress-related factors (including stressful life events, traumatic life events or comorbid PTSD) may respond better or worse to the available treatments; and comorbid PTSD may modify the clinical expression of OCD-although controlled studies comparing pre-versus post-traumatic OCD patients are still unavailable. In conclusion, there is a growing evidence to suggest a role for stress-related factors in OCD. Although the available literature does not confirm the existence of a post-traumatic subtype of OCD, it does call for further systematic research into this topic. © 2011 Future Medicine Ltd.en
dc.description.affiliationAnxiety and Depression Research Program Institute of Psychiatry Universidade Federal do Rio de Janeiro, Rua Visconde de Pirajá, 547, Ipanema, Rio de Janeiro
dc.description.affiliationDepartment of Psychiatry and Mental Health Institute of Community Health Universidade Federal Fluminense
dc.description.affiliationMelbourne Neuropsychiatry Centre University of Melbourne and Melbourne Health
dc.description.affiliationDepartment of Psychiatry University of São Paulo Medical School
dc.description.affiliationDepartment of Neurology, Psychology and Psychiatry Botucatu Medical School Universidade Estadual Paulista
dc.description.affiliationUnespDepartment of Neurology, Psychology and Psychiatry Botucatu Medical School Universidade Estadual Paulista
dc.format.extent61-69
dc.identifierhttp://dx.doi.org/10.2217/npy.10.1
dc.identifier.citationNeuropsychiatry, v. 1, n. 1, p. 61-69, 2011.
dc.identifier.doi10.2217/npy.10.1
dc.identifier.issn1758-2008
dc.identifier.issn1758-2016
dc.identifier.lattes3837157956819433
dc.identifier.scopus2-s2.0-84856219468
dc.identifier.urihttp://hdl.handle.net/11449/72304
dc.language.isoeng
dc.relation.ispartofNeuropsychiatry
dc.relation.ispartofsjr0,429
dc.relation.ispartofsjr0,429
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectserotonin uptake inhibitor
dc.subjectagoraphobia
dc.subjectcognitive therapy
dc.subjectcomorbidity
dc.subjectcomparative study
dc.subjectdisease association
dc.subjectdisease course
dc.subjectdisease severity
dc.subjecthuman
dc.subjectlife event
dc.subjectmajor depression
dc.subjectobsessive compulsive disorder
dc.subjectoutcome assessment
dc.subjectpanic
dc.subjectposttraumatic stress disorder
dc.subjectpriority journal
dc.subjectprognosis
dc.subjectreview
dc.subjectsocial phobia
dc.subjectstressful life event
dc.subjecttraumatic life event
dc.subjecttrichotillomania
dc.subjectYale Brown Obsessive Compulsive Scale
dc.titleRole of stressful and traumatic life events in obsessive-compulsive disorderen
dc.typeResenha
dcterms.licensehttp://www.futuremedicine.com/page/Permissions
unesp.author.lattes3837157956819433[5]
unesp.author.orcid0000-0003-1072-5008[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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