Evolution of the Metazoan Mitochondrial Replicase

dc.contributor.authorOliveira, Marcos T. [UNESP]
dc.contributor.authorHaukka, Jani
dc.contributor.authorKaguni, Laurie S.
dc.contributor.institutionUniversity of Tampere
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionMichigan State University
dc.date.accessioned2015-10-21T20:30:40Z
dc.date.available2015-10-21T20:30:40Z
dc.date.issued2015-04-01
dc.description.abstractThe large number of complete mitochondrial DNA (mtDNA) sequences available for metazoan species makes it a good system for studying genome diversity, although little is known about the mechanisms that promote and/or are correlated with the evolution of this organellar genome. By investigating the molecular evolutionary history of the catalytic and accessory subunits of the mtDNA polymerase, pol gamma, we sought to develop mechanistic insight into its function that might impact genome structure by exploring the relationships between DNA replication and animal mitochondrial genome diversity. We identified three evolutionary patterns among metazoan pol gamma s. First, a trend toward stabilization of both sequence and structure occurred in vertebrates, with both subunits evolving distinctly from those of other animal groups, and acquiring at least four novel structural elements, the most important of which is the HLH-3 beta (helix-loop-helix, 3 beta-sheets) domain that allows the accessory subunit to homodimerize. Second, both subunits of arthropods and tunicates have become shorter and evolved approximately twice as rapidly as their vertebrate homologs. And third, nematodes have lost the gene for the accessory subunit, which was accompanied by the loss of its interacting domain in the catalytic subunit of pol gamma, and they show the highest rate of molecular evolution among all animal taxa. These findings correlate well with the mtDNA genomic features of each group described above, and with their modes of DNA replication, although a substantive amount of biochemical work is needed to draw conclusive links regarding the latter. Describing the parallels between evolution of pol gamma and metazoan mtDNA architecture may also help in understanding the processes that lead to mitochondrial dysfunction and to human disease-related phenotypes.en
dc.description.affiliationInstitute of Biosciences and Medical Technology, University of Tampere, Finland
dc.description.affiliationDepartment of Biochemistry and Molecular Biology and Center for Mitochondrial Science and Medicine, Michigan State University
dc.description.affiliationUnespDepartamento de Tecnologia, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista “Júlio de Mesquita Filho,” Jaboticabal, SP, Brazil
dc.description.sponsorshipNational Institutes of Health
dc.description.sponsorshipMarie Curie International Incoming Fellowship from the European Union
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipUniversity of Tampere
dc.description.sponsorshipFinland Distinguished Professor Programme of the Academy of Finland
dc.description.sponsorshipIdNational Institutes of Health: 45295
dc.description.sponsorshipIdMarie Curie International Incoming Fellowship from the European Union: GA328988
dc.description.sponsorshipIdFAPESP: 2014/02253-6
dc.format.extent943-959
dc.identifierhttp://gbe.oxfordjournals.org/content/7/4/943
dc.identifier.citationGenome Biology And Evolution. Oxford: Oxford Univ Press, v. 7, n. 4, p. 943-959, 2015.
dc.identifier.doi10.1093/gbe/evv042
dc.identifier.fileWOS000355148800002.pdf
dc.identifier.issn1759-6653
dc.identifier.urihttp://hdl.handle.net/11449/129173
dc.identifier.wosWOS:000355148800002
dc.language.isoeng
dc.publisherOxford Univ Press
dc.relation.ispartofGenome Biology And Evolution
dc.relation.ispartofjcr3.940
dc.relation.ispartofsjr2,578
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectMitochondriaen
dc.subjectMitochondrial DNA replicationen
dc.subjectStructural evolutionen
dc.subjectMitochondrial replicaseen
dc.subjectPol gammaen
dc.titleEvolution of the Metazoan Mitochondrial Replicaseen
dc.typeArtigo
dcterms.licensehttp://www.oxfordjournals.org/access_purchase/self-archiving_policyb.html
dcterms.rightsHolderOxford Univ Press
unesp.author.orcid0000-0003-4779-5755[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt
unesp.departmentTecnologia - FCAVpt

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