Ultrastructural changes on the hard palatine mucosa of Calomys callosus after 120 days of experimental chronic alcoholism

Página do item simplificado
dc.contributor.authorMartinez, M.
dc.contributor.authorMilton, F. A.
dc.contributor.authorDe Oliveira, S. A.
dc.contributor.authorDe Lima, N. F.
dc.contributor.authorSegatelli, T. M.
dc.contributor.authorPinheiro, P. F.F.
dc.contributor.authorAlmeida, C. C.D.
dc.contributor.authorMello, W.
dc.contributor.authorQuitete, V. H.A.C.
dc.contributor.authorMartinez, F. E.
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2022-04-29T08:42:59Z
dc.date.available2022-04-29T08:42:59Z
dc.date.issued2005-04-01
dc.description.abstractThe present study analyzed the toxic effects of chronic alcohol ingestion on the ultrastructure of the lining epithelium of the hard palatine mucosa of the rodent Calomys callosus, in order to contribute to the understanding of the consequences of alcohol abuse for the morphology of the digestive system. Twenty-six adult animals aged three months were divided into two experimental groups. The control group received a solid diet and tap water, and the alcoholic group received the same solid diet and ethanol P.A. diluted 20% in water (v/v). After 120 days of treatment, all animals were anaesthetised, weighed and sacrificed. At the end of treatment, mean body weight did not differ between control and alcoholic animals. The epithelial cells of the alcoholic group showed many alterations such as the presence of lipid droplets, nuclei in corneum layer, nuclei with increase peripheral chromatin and greater electron density, altered mitochondria, and intense dilatation of the intercellular spaces. It was concluded that 20% ethanol provokes marked ultrastructural lesions in the hard palatine mucosa.en
dc.description.affiliationDepartment of Morphology and Pathology Federal University of São Carlos, SP
dc.description.affiliationDepartment of Anatomy University of Campinas, SP
dc.description.affiliationDepartment of Anatomy State University of São Paulo, Botucatu, SP
dc.description.affiliationDepartamento de Morfologia e Patologia Universidade Federal de São Carlos, Rod. Washington Luis Km 235 s/n, CEP: 13.565.905, São Carlos/SP
dc.format.extent59-65
dc.identifier.citationJournal of Submicroscopic Cytology and Pathology, v. 37, n. 1, p. 59-65, 2005.
dc.identifier.issn1122-9497
dc.identifier.scopus2-s2.0-23244458047
dc.identifier.urihttp://hdl.handle.net/11449/230991
dc.language.isoeng
dc.relation.ispartofJournal of Submicroscopic Cytology and Pathology
dc.sourceScopus
dc.subjectAlcoholism
dc.subjectCalomys callosus
dc.subjectEpithelium
dc.subjectHard palate
dc.subjectLamina propria
dc.subjectMucosa
dc.titleUltrastructural changes on the hard palatine mucosa of Calomys callosus after 120 days of experimental chronic alcoholismen
dc.typeArtigo

Arquivos

Coleções

Artigos - Anatomia - IBB