Local application of tetracycline solution with a microbrush: An alternative treatment for persistent periodontitis

dc.contributor.authorBosco, Joseane M. D. [UNESP]
dc.contributor.authorLopes, Beatriz M. V. [UNESP]
dc.contributor.authorBosco, Álvaro Francisco [UNESP]
dc.contributor.authorSpolidorio, Denise M. P. [UNESP]
dc.contributor.authorMarcantonio, Rosemary Adriana Chierici [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2013-09-30T18:32:24Z
dc.date.accessioned2014-05-20T13:43:12Z
dc.date.available2013-09-30T18:32:24Z
dc.date.available2014-05-20T13:43:12Z
dc.date.issued2009-01-01
dc.description.abstractObjective: Topical antibiotics may overcome shortcomings of mechanical therapy for localized persistent periodontitis. This double-center, single-blind, randomized controlled study aimed to evaluate the microbiologic profile and clinical parameters of persistent periodontal pockets after treatment with tetracycline solution. Method and Materials: Thirty-seven patients who had at least 4 nonadjacent sites of persistent periodontal pockets with probing depth of at least 5 mm and bleeding on probing were randomly assigned to test and control groups. In the test group, 2 teeth received 4 applications of tetracycline solution (100 mg/mL) with a microbrush (T), while the other 2 teeth received the same treatment plus 1 session of scaling and root planing (SRP+T). In the control group, 2 teeth received 1 session of scaling and root planing (SRP), and the other 2 teeth received 4 applications of saline with a microbrush plus 1 session of scaling and root planing (SRP+S). Clinical parameters of probing depth, bleeding on probing, visible plaque index, gingival bleeding index, gingival recession, as well as clinical attachment level and subgingival plaque samples (evaluated by polymerase chain reaction) were measured at baseline and 1, 3, and 6 months. Results: All therapies yielded statistically significant data on clinical measurements with no significant differences among groups. Presence of bacteria decreased in both groups, but only in the test group was a significant decrease of Porphyromonas gingivalis, Tannerella forsythia, and Actinobacillus actinomycetemcomitans noted up to 6 months. Conclusion: Tetracycline applied with a microbrush may be an alternative treatment for persistent periodontitis that can probably be mediated by reduction of microorganism proliferation. (Quintessence Int 2009; 40: 29-40)en
dc.description.affiliationUniv Estadual Paulista, Dept Periodontol, Dent Sch Araraquara, BR-14801903 São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Sch Dent Aracatuba, Dept Surg, BR-14801903 São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Sch Dent Aracatuba, Integrated Clin, BR-14801903 São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Sch Dent Araraquara, Dept Physiol & Pathol, BR-14801903 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Periodontol, Dent Sch Araraquara, BR-14801903 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Sch Dent Aracatuba, Dept Surg, BR-14801903 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Sch Dent Aracatuba, Integrated Clin, BR-14801903 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Sch Dent Araraquara, Dept Physiol & Pathol, BR-14801903 São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 03/10598-9
dc.format.extent29-40
dc.identifierhttp://www.quintpub.com/journals/qi/abstract.php?article_id=3725#.UjDSacZwp5I
dc.identifier.citationQuintessence International. Hanover Park: Quintessence Publishing Co Inc, v. 40, n. 1, p. 29-40, 2009.
dc.identifier.issn0033-6572
dc.identifier.lattes9831236034935598
dc.identifier.urihttp://hdl.handle.net/11449/15045
dc.identifier.wosWOS:000265647300004
dc.language.isoeng
dc.publisherQuintessence Publishing Co Inc
dc.relation.ispartofQuintessence International
dc.relation.ispartofjcr1.088
dc.relation.ispartofsjr0,563
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectcomparative studyen
dc.subjectperiodontal disease/drug therapyen
dc.subjectperiodontal disease/microbiologyen
dc.subjecttetracycline/therapeutic useen
dc.titleLocal application of tetracycline solution with a microbrush: An alternative treatment for persistent periodontitisen
dc.typeArtigo
dcterms.licensehttp://www.quintpub.com/journals/jop/orderreprints.php
dcterms.rightsHolderQuintessence Publishing Co Inc
unesp.author.lattes3534044399884035
unesp.author.orcid0000-0003-2376-1024[4]
unesp.author.orcid0000-0002-5052-7439[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

Arquivos

Licença do Pacote
Agora exibindo 1 - 2 de 2
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição: