Reconstruction of molecular networks involved in citokine-induced myotubes atrophy integrating microRNA and mRNA expression
Carregando...
Arquivos
Data
2013-09-26
Autores
Orientador
Pai, Maeli Dal 
Carvalho, Robson Francisco
Coorientador
Pós-graduação
Ciências Biológicas (Genética) - IBB
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Estadual Paulista (Unesp)
Tipo
Dissertação de mestrado
Direito de acesso
Acesso aberto
Resumo
The skeletal muscle atrophy is a common phenomenon in many chronic systemic diseases such a sepsis, chronic heart failure, chronic obstructive pulmonary disease, chronic kidney disease, diabetes, AIDS and cancer. These diseases may be accompanied by a complex metabolic syndrome characterized by muscle wasting, denominated cachexia. The molecular pathways responsible for cachexia are not completely understood, however, evidence suggest that pro-inflammatory cytokines like Tumor Necrosis Factor (TNF)-α and Interferon (INF)-γ have a key role in molecular pathways related to loss of function and muscle mass. The complexity of mechanisms controlling gene expression in this process suggests the involvement of additional regulatory molecules, such as microRNAs; these RNA molecules encoded by the genome regulate the function of skeletal muscle during development and various muscle diseases. MicroRNAs orchestrate common pathways or biological function, this unique feature gives rise as an effective tool for determining the pathways involved in specific diseases or biological processes. The hypothesis of this work is that the muscle atrophy induced by TNF-α and INF-γ has a microRNAs expression profile that allow the identification of regulatory networks and molecular pathways
Descrição
Palavras-chave
Idioma
Português
Como citar
FERNANDEZ GARCIA, Geysson Javier. Reconstruction of molecular networks involved in citokine-induced myotubes atrophy integrating microRNA and mRNA expression. 2013. 93 f. Dissertação (mestrado) - Universidade Estadual Paulista Julio de Mesquita Filho, Instituto de Biociências de Botucatu, 2013.