Zinc supplementation does not inhibit basal and metoclopramide-stimulated prolactinemia secretion in healthy men

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dc.contributor.authorCastro, AVB
dc.contributor.authorMendonca, B. B.
dc.contributor.authorBloise, W.
dc.contributor.authorShuhama, T.
dc.contributor.authorBrandao-Neto, J.
dc.contributor.institutionUniversidade Federal do Rio Grande do Norte (UFRN)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:25:30Z
dc.date.available2014-05-20T15:25:30Z
dc.date.issued2002-01-01
dc.description.abstractDopamine (DA) and zinc (Zn++) share common mechanisms in their inhibition of prolactin (PRL) secretion. Both substances are present in the same brain areas, where Zn++ is released together with DA, suggesting a modulatory effect of Zn++ on dopaminergic receptors. The aim of the present study was to evaluate the effect of Zn supplementation on basal and PRL secretion stimulated by metoclopramide (MCP), a dopaminergic antagonist. Seven healthy men were evaluated in controlled study, where MCP (5 mg) was given intravenously, before and after 3 months of oral Zn++ (25 mg) administration. Our results indicate that chronic Zn++ administration does not change basal or MCP-stimulated plasma PRL secretion suggesting that, in humans, Zn++ does not interfere on PRL secretion mediated through dopaminergic receptors.en
dc.description.affiliationUniv Fed Rio Grande Norte, Ctr Ciências Saude, Unidade Endocrinol & Metab, BR-59072970 Natal, RN, Brazil
dc.description.affiliationUniv São Paulo, Fac Med, Unidade Endocrinol, BR-05508900 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Ciências Farmaceut, Lab Quim Analit, BR-14049 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Fac Med, Unidade Endocrinol & Metab, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Fac Med, Unidade Endocrinol & Metab, Botucatu, SP, Brazil
dc.format.extent69-73
dc.identifierhttp://dx.doi.org/10.1016/S0946-672X(02)80031-1
dc.identifier.citationJournal of Trace Elements In Medicine and Biology. Jena: Urban & Fischer Verlag, v. 16, n. 2, p. 69-73, 2002.
dc.identifier.doi10.1016/S0946-672X(02)80031-1
dc.identifier.issn0946-672X
dc.identifier.urihttp://hdl.handle.net/11449/35919
dc.identifier.wosWOS:000177406700001
dc.language.isoeng
dc.publisherUrban & Fischer Verlag
dc.relation.ispartofJournal of Trace Elements In Medicine and Biology
dc.relation.ispartofjcr3.755
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectzinc supplementationpt
dc.subjectprolactin secretionpt
dc.subjectmetoclopramidept
dc.subjecthealthy menpt
dc.titleZinc supplementation does not inhibit basal and metoclopramide-stimulated prolactinemia secretion in healthy menen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderUrban & Fischer Verlag
unesp.author.orcid0000-0003-1762-1084[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentClínica Médica - FMBpt

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