Human platelets antigens influence the viral load of platelets after the interaction of the platelets with HCV and HIV in vitro

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dc.contributor.authorTommasini Grotto, Rejane Maria [UNESP]
dc.contributor.authorCantao, Natalia Mirele [UNESP]
dc.contributor.authorPadovani, Juliana Lara [UNESP]
dc.contributor.authorSouza, Lenice do Rosario de [UNESP]
dc.contributor.authorSilva, Giovanni Faria [UNESP]
dc.contributor.authorFerrasi, Adriana Camargo [UNESP]
dc.contributor.authorMoura Campos Pardini, Maria Ines de [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-11-26T17:04:27Z
dc.date.available2018-11-26T17:04:27Z
dc.date.issued2016-07-01
dc.description.abstractIntroduction: In this study, we evaluated hepatitis C virus (HCV) and human immunodeficiency virus (HIV) - platelet interactions in vitro as well as human platelets antigen (HPA) polymorphisms. Methods: Platelets were obtained from 100 healthy HPA-genotyped volunteer donors and incubated with HIV or HCV. The viral load after in vitro exposure was detected. Results: The viral load in the platelets after exposure to the virus was higher in the HIV exposure than in the HCV exposure. Conclusions: HIV-platelet ligation could be more efficient than HCV-platelet interaction. Further, the HPA-1b allele seems to influence the interaction of platelets with HCV.en
dc.description.affiliationUniv Estadual Paulista, Fac Med Botucatu, Hemoctr Botucatu, Lab Biol Mol, Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Agron, Dept Bioproc & Biotecnol, Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Med Botucatu, Dept Doencas Tropicais & Diagnost Imagem, Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Med Botucatu, Dept Clin Med, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Med Botucatu, Hemoctr Botucatu, Lab Biol Mol, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias Agron, Dept Bioproc & Biotecnol, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Med Botucatu, Dept Doencas Tropicais & Diagnost Imagem, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Med Botucatu, Dept Clin Med, Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent491-493
dc.identifierhttp://dx.doi.org/10.1590/0037-8682-0105-2016
dc.identifier.citationRevista Da Sociedade Brasileira De Medicina Tropical. Brasilia: Soc Brasileira Medicina Tropical, v. 49, n. 4, p. 491-493, 2016.
dc.identifier.doi10.1590/0037-8682-0105-2016
dc.identifier.fileS0037-86822016000400491.pdf
dc.identifier.issn0037-8682
dc.identifier.lattes3587895085226224
dc.identifier.lattes5020559826568182
dc.identifier.orcid0000-0001-9200-5391
dc.identifier.orcid0000-0003-1948-5071
dc.identifier.scieloS0037-86822016000400491
dc.identifier.urihttp://hdl.handle.net/11449/161869
dc.identifier.wosWOS:000382457200015
dc.language.isoeng
dc.publisherSoc Brasileira Medicina Tropical
dc.relation.ispartofRevista Da Sociedade Brasileira De Medicina Tropical
dc.relation.ispartofsjr0,658
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectHepatitis C virus
dc.subjectHuman platelets antigen polymorphisms
dc.subjectHuman immunodeficiency virus
dc.titleHuman platelets antigens influence the viral load of platelets after the interaction of the platelets with HCV and HIV in vitroen
dc.typeArtigo
dcterms.rightsHolderSoc Brasileira Medicina Tropical
unesp.author.lattes3587895085226224[6]
unesp.author.lattes5020559826568182[4]
unesp.author.orcid0000-0001-9200-5391[6]
unesp.author.orcid0000-0003-1948-5071[4]

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