Biodegradable scaffolds based on plant stems for application in regenerative medicine

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dc.contributor.authorFerranti, Carolina Costa
dc.contributor.authorAlves, Eduardo Donato
dc.contributor.authorLopes, Camila Soares [UNESP]
dc.contributor.authorMontrezor, Luís Henrique
dc.contributor.authorCarvalho, Antonio José Felix
dc.contributor.authorCerri, Paulo Sérgio [UNESP]
dc.contributor.authorTrovatti, Eliane
dc.contributor.institutionUniversity of Araraquara - UNIARA
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2023-07-29T15:34:47Z
dc.date.available2023-07-29T15:34:47Z
dc.date.issued2023-01-01
dc.description.abstractSeveral synthetic and natural materials have been studied for the confection of temporary grafts for application in regenerative medicine, however, the development of a material with adequate properties remains a challenge, mainly because its degradation kinetics in biological systems. Nature provides materials with noble properties that can be used as such for many applications, thus, taking advantage of the available morphology and assembled structures of plants, we propose to study the vegetable stems for use as temporary graft. Since the in vivo degradation is maybe one of the most important features of the temporary grafts, here we have implanted the plant stems from pumpkin, papaya, and castor into the subepithelial tissue of animals and followed their biodegradation process and the local inflammatory response. Mechanical tests, FTIR and contact angle with water were also analysed. The results indicated the mechanical properties and the contact angle were adequate for use in regenerative medicine. The results of the in vivo studies indicated a beneficial inflammatory process and a gradual disintegration of the materials within 60 days, suggesting the plants stems as new and potential materials for development of grafts for use in the field of regenerative medicine.en
dc.description.affiliationUniversity of Araraquara - UNIARA, Rua Carlos Gomes, 1217 SP
dc.description.affiliationLaboratory of Histology and Embryology Department of Morphology Genetics Orthodontics and Pediatric Dentistry - Dental School—São Paulo State University (UNESP), SP
dc.description.affiliationDepartment of Materials Engineering São Carlos School of Engineering University of Sao Paulo, Av. João Dagnone SP
dc.description.affiliationUnespLaboratory of Histology and Embryology Department of Morphology Genetics Orthodontics and Pediatric Dentistry - Dental School—São Paulo State University (UNESP), SP
dc.identifierhttp://dx.doi.org/10.1088/2057-1976/ac9fda
dc.identifier.citationBiomedical Physics and Engineering Express, v. 9, n. 1, 2023.
dc.identifier.doi10.1088/2057-1976/ac9fda
dc.identifier.issn2057-1976
dc.identifier.scopus2-s2.0-85142940202
dc.identifier.urihttp://hdl.handle.net/11449/249424
dc.language.isoeng
dc.relation.ispartofBiomedical Physics and Engineering Express
dc.sourceScopus
dc.subjectcarica papaya L
dc.subjectcucurbita máxima L
dc.subjectIn vivo degradation
dc.subjectricinus communis L
dc.subjecttemporary vegetable scaffolds
dc.titleBiodegradable scaffolds based on plant stems for application in regenerative medicineen
dc.typeArtigo
unesp.author.orcid0000-0001-5756-5828[6]
unesp.author.orcid0000-0002-0495-8115[7]

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