Antimicrobial photodynamic therapy in rat experimental candidiasis: evaluation of pathogenicity factors of Candida albicans

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dc.contributor.authorMartins, Joyce da Silva [UNESP]
dc.contributor.authorJunqueira, Juliana Campos
dc.contributor.authorFaria, Raquel Lourdes
dc.contributor.authorSantiago, Naiara Fonseca
dc.contributor.authorRossoni, Rodnei Dennis
dc.contributor.authorDias Colombo, Carlos Eduardo
dc.contributor.authorCardoso Jorge, Antonio Olavo
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Taubate UNI TAU
dc.date.accessioned2015-03-18T15:54:07Z
dc.date.available2015-03-18T15:54:07Z
dc.date.issued2011-01-01
dc.description.abstractObjective. This study evaluated the effects of photodynamic therapy on pathogenicity of Candida albicans.Study design. Fifty-six rats were submitted to development of candidiasis on the tongue dorsum by C. albicans inoculations. After 5 days, different treatments were administered: laser and photosynthesizer methylene blue (L+P+); laser only (L+P-); photosensitizer only (L-P+);and physiologic solution only (L-P-). Samples of the oral cavity were collected for a count of colony-forming units per mL. Colonies were isolated for evaluation of proteinase and phospholipase activities. The rats were killed for microscopic analysis of the tongue dorsum. The data were analyzed by analysis of variance, Kruskal-Wallis, and Bonferroni tests.Results. The number of C. albicans recovered from the oral cavity of the rats was similar between the groups (P = .106). The L+P+ group showed fewer microscopic lesions of candidiasis than the L-P- group (P = .001). The L+P+ group presented lower proteinase activity compared with the other groups, with significant difference between the groups L+P+ and L-P+ (P = .018).Conclusions. Photodynamic therapy reduced the microscopic lesions of experimental candidiasis in rats and inhibited the proteinase activity of C. albicans. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011;111:71-77)en
dc.description.affiliationSao Paulo State Univ UNESP, Sch Dent Sao Jose dos Campos, Dept Biosci & Oral Diag, Sao Paulo, Brazil
dc.description.affiliationUniv Taubate UNI TAU, Dept Dent, Sao Paulo, Brazil
dc.description.affiliationUnespSao Paulo State Univ UNESP, Sch Dent Sao Jose dos Campos, Dept Biosci & Oral Diag, Sao Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 07/58780-0
dc.format.extent71-77
dc.identifierhttp://dx.doi.org/10.1016/j.tripleo.2010.08.012
dc.identifier.citationOral Surgery Oral Medicine Oral Pathology Oral Radiology And Endodontology. New York: Mosby-elsevier, v. 111, n. 1, p. 71-77, 2011.
dc.identifier.doi10.1016/j.tripleo.2010.08.012
dc.identifier.issn1079-2104
dc.identifier.lattes0322020541055900
dc.identifier.lattes0053567153623569
dc.identifier.urihttp://hdl.handle.net/11449/116778
dc.identifier.wosWOS:000285504200028
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofOral Surgery Oral Medicine Oral Pathology Oral Radiology And Endodontology
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleAntimicrobial photodynamic therapy in rat experimental candidiasis: evaluation of pathogenicity factors of Candida albicansen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes0322020541055900
unesp.author.lattes0053567153623569[7]
unesp.author.orcid0000-0002-1747-6158[7]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campospt

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