Analysis of GLT6D1 and CDKN2BAS gene polymorphisms in Brazilian patients with advanced periodontitis

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dc.contributor.authorRodrigues, Richelle Soares
dc.contributor.authorRêgo, Rodrigo
dc.contributor.authorCaminaga, Raquel Mantuaneli Scarel [UNESP]
dc.contributor.authorGoveia, Jéssica Marina [UNESP]
dc.contributor.authorSilveira, Virginia Régia Souza
dc.contributor.institutionDentistry and Nursing
dc.contributor.institutionUniversidade Federal do Ceará – UFC. School of Dentistry at Sobral
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-03-01T20:50:10Z
dc.date.available2023-03-01T20:50:10Z
dc.date.issued2022-01-01
dc.description.abstractGene polymorphisms can predispose to periodontal disease, as demonstrated by the well-documented association between aggressive periodontitis and single nucleotide polymorphisms (SNPs) such as rs153745 in the GLT6D1 gene and rs3217992 in the CDKN2BAS gene. The purpose of this study was to evaluate the presence of these SNPs in Brazilian patients with advanced periodontitis (stages III/IV, Grade B/C) vs. healthy controls. A total of 100 patients with periodontitis (Group BC) were enrolled. Of these, 51 patients were classified as stage III and 49 patients were classified as stage IV, and 52 were Grade B (Group B) and 48 were Grade C (Group C). The control Group consisted of 61 healthy subjects. DNA samples extracted from buccal epithelial cells were used to genotype the SNPs rs1537415 (GLT6D1) and rs3217992 (CDKN2BAS) by real-time quantitative PCR. No significant differences in polymorphism frequency were found between the control Group and each of the patient groups (BC, B, or C), and Group B did not differ from Group C. In conclusion, the evaluated SNPs had no significant influence on the prevalence of periodontal disease in the sampled Brazilian population.en
dc.description.affiliationUniversidade Federal do Ceará – UFC Faculty of Pharmacy Dentistry and Nursing Department of Clinical Dentistry, CE
dc.description.affiliationUniversidade Federal do Ceará – UFC. School of Dentistry at Sobral Department of Dentistry, CE
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho - Unesp School of Dentistry at Araraquara Department of Morphology, SP
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho - Unesp School of Dentistry at Araraquara Department of Morphology, SP
dc.identifierhttp://dx.doi.org/10.1590/1807-3107BOR-2022.VOL36.0077
dc.identifier.citationBrazilian Oral Research, v. 36.
dc.identifier.doi10.1590/1807-3107BOR-2022.VOL36.0077
dc.identifier.issn1807-3107
dc.identifier.issn1806-8324
dc.identifier.scopus2-s2.0-85132080686
dc.identifier.urihttp://hdl.handle.net/11449/241169
dc.language.isoeng
dc.relation.ispartofBrazilian Oral Research
dc.sourceScopus
dc.subjectGenetic
dc.subjectPeriodontitis
dc.subjectPolymorphism
dc.subjectSingle nucleotide
dc.titleAnalysis of GLT6D1 and CDKN2BAS gene polymorphisms in Brazilian patients with advanced periodontitisen
dc.typeArtigo
unesp.author.orcid0000-0002-2228-7888[1]
unesp.author.orcid0000-0001-5250-5738[2]
unesp.author.orcid0000-0001-5068-0268[3]
unesp.author.orcid0000-0002-6930-5828[4]
unesp.author.orcid0000-0002-4926-7043[5]

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