Maternal periodontal disease in rats decreases insulin sensitivity and insulin signaling in adult offspring

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dc.contributor.authorShirakashi, Daisy J. [UNESP]
dc.contributor.authorLeal, Rosana P. [UNESP]
dc.contributor.authorColombo, Natalia H. [UNESP]
dc.contributor.authorChiba, Fernando Y. [UNESP]
dc.contributor.authorGarbin, Cléa A.S. [UNESP]
dc.contributor.authorJardim Jr., Elerson G. [UNESP]
dc.contributor.authorSilva, Cristina Antoniali [UNESP]
dc.contributor.authorSumida, Doris Hissako [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:28:36Z
dc.date.available2014-05-27T11:28:36Z
dc.date.issued2013-03-01
dc.description.abstractBackground: Periodontal disease during pregnancy has been recognized as one of the causes of preterm and lowbirth- weight (PLBW) babies. Several studies have demonstrated that PLBW babies are prone to developing insulin resistance as adults. Although there is controversy over the association between periodontal disease and PLBW, the phenomenon known as programming can translate any stimulus or aggression experienced during intrauterine growth into physiologic and metabolic alterations in adulthood. The purpose of the present study is to investigate whether the offspring of rats with periodontal disease develop insulin resistance in adulthood. Methods: Ten female Wistar rats were divided into periodontal disease (PED) and control (CN) groups. All rats were mated at 7 days after induction of periodontal disease. Male offspring were divided into two groups: 1) periodontal disease offspring (PEDO; n = 24); and 2) control offspring (CNO; n = 24). Offspring body weight was measured from birth until 75 days. When the offspring reached 75 days old, the following parameters were measured: 1) plasma concentrations of glucose, insulin, fructosamine, lipase, amylase, and tumor necrosis factor-α (TNF-α); 2) insulin sensitivity (IS); and 3) insulin signal transduction (IST) in insulin-sensitive tissues. Results: Low birth weight was not detected in the PEDO group. However, plasma concentrations of glucose, insulin, fructosamine, lipase, amylase, and TNF-α were increased and IS and IST were reduced (P <0.05) in the PEDO group compared with the CNO group. Conclusion: Maternal periodontal disease may induce insulin resistance and reduce IST in adult offspring, but such alterations are not attributable to low birth weight.en
dc.description.affiliationDepartment of Basic Sciences Dental School of Araçatuba São Paulo State University, R. José Bonifácio, 1193, 16015-050, Araçatuba, SP
dc.description.affiliationDepartment of Child and Social Dentistry Dental School of Araçatuba São Paulo State University
dc.description.affiliationDepartment of Pathology and Propedeutics Dental School of Araçatuba São Paulo State University
dc.description.affiliationUnespDepartment of Basic Sciences Dental School of Araçatuba São Paulo State University, R. José Bonifácio, 1193, 16015-050, Araçatuba, SP
dc.description.affiliationUnespDepartment of Child and Social Dentistry Dental School of Araçatuba São Paulo State University
dc.description.affiliationUnespDepartment of Pathology and Propedeutics Dental School of Araçatuba São Paulo State University
dc.format.extent407-414
dc.identifierhttp://dx.doi.org/10.1902/jop.2012.110372
dc.identifier.citationJournal of Periodontology, v. 84, n. 3, p. 407-414, 2013.
dc.identifier.doi10.1902/jop.2012.110372
dc.identifier.issn0022-3492
dc.identifier.lattes6656433539493879
dc.identifier.lattes8275401688702343
dc.identifier.lattes4419158525709686
dc.identifier.orcid0000-0001-5069-8812
dc.identifier.scopus2-s2.0-84874585054
dc.identifier.urihttp://hdl.handle.net/11449/74752
dc.identifier.wosWOS:000316162700016
dc.language.isoeng
dc.relation.ispartofJournal of Periodontology
dc.relation.ispartofjcr3.392
dc.relation.ispartofsjr1,408
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectCytokines
dc.subjectDiabetes mellitus
dc.subjectInflammation
dc.subjectInsulin resistance
dc.subjectPeriodontal diseases
dc.subjectamylase
dc.subjectfructosamine
dc.subjectinsulin
dc.subjecttriacylglycerol lipase
dc.subjecttumor necrosis factor alpha
dc.subjectanimal
dc.subjectbirth weight
dc.subjectblood
dc.subjectfemale
dc.subjectglucose blood level
dc.subjectinsulin resistance
dc.subjectmale
dc.subjectmetabolism
dc.subjectnewborn
dc.subjectpathophysiology
dc.subjectperiodontitis
dc.subjectphysiology
dc.subjectpregnancy
dc.subjectpregnancy complication
dc.subjectprenatal exposure
dc.subjectradiography
dc.subjectrat
dc.subjectsignal transduction
dc.subjectWistar rat
dc.subjectAmylases
dc.subjectAnimals
dc.subjectAnimals, Newborn
dc.subjectBirth Weight
dc.subjectBlood Glucose
dc.subjectFemale
dc.subjectFructosamine
dc.subjectInsulin
dc.subjectInsulin Resistance
dc.subjectLipase
dc.subjectMale
dc.subjectPeriodontitis
dc.subjectPregnancy
dc.subjectPregnancy Complications
dc.subjectPrenatal Exposure Delayed Effects
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSignal Transduction
dc.subjectTumor Necrosis Factor-alpha
dc.titleMaternal periodontal disease in rats decreases insulin sensitivity and insulin signaling in adult offspringen
dc.typeArtigo
dcterms.licensehttp://www.joponline.org/userimages/ContentEditor/1124388816475/Instructions_to_Authors.pdf
unesp.author.lattes6656433539493879
unesp.author.lattes8275401688702343
unesp.author.lattes4419158525709686[5]
unesp.author.orcid0000-0001-5069-8812[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt

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Artigos - Ciências Básicas - FOA
Artigos - Odontologia Infantil e Social - FOA
Artigos - Patologia e Propedêutica Clínica - FOA