Compounds of Anthostomella brabeji, an endophytic fungus isolated from Paepalanthus planifolius (Eriocaulaceae)

dc.contributor.authorDe Amorim, Marcelo R. [UNESP]
dc.contributor.authorSomensi, Andressa [UNESP]
dc.contributor.authorAraujo, Angela R. [UNESP]
dc.contributor.authorBonifácio, Bruna V. [UNESP]
dc.contributor.authorBauab, Tais M. [UNESP]
dc.contributor.authorSantos, Lourdes C. Dos [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:03:16Z
dc.date.available2018-12-11T17:03:16Z
dc.date.issued2016-06-01
dc.description.abstractIn this study, fifteen endophytic fungi were isolated from Paepalanthus planifolius (Eriocaulaceae). From the capitula, seven endophytes were screened and evaluated for their metabolomic profile and radical scavenging activity (2,2-diphenyl-1-picrylhydrazyl (DPPH) assay). Chemical investigation of ethyl acetate extract of the endophytic fungus Anthostomella brabeji resulted in the isolation of one new compound, (+)-(6R∗,7S∗,8R∗)-6,7,8-trihydroxy-2,2-dimethyl-5,6,7,8-tetrahydro-chroman-4-one, and three known compounds: 6-hydroxy-2,2-dimethyl-5,6,7,8-tetrahydro-7,8-epoxycroman-4-one, siccayne and eutypinol. All of the compound structures were elucidated using 1D and 2D nuclear magnetic resonance (NMR) and mass spectrometry (MS) analyses. The antimicrobial activity of the compounds and A. brabeji extract were assayed against the microorganisms Staphylococcus aureus, Escherichia coli, Salmonella setubal and Candida albicans. Measured minimal inhibitory concentration (MIC) values ranged from 31.25 to 1000.0 μg mL-1.en
dc.description.affiliationDepartamento de Química Orgânica Instituto de Química Universidade Estadual Paulista (UNESP)
dc.description.affiliationDepartamento de CiênciasBiológicas Escola de Ciências Farmacêuticas Universidade Estadual Paulista (UNESP)
dc.description.affiliationUnespDepartamento de Química Orgânica Instituto de Química Universidade Estadual Paulista (UNESP)
dc.description.affiliationUnespDepartamento de CiênciasBiológicas Escola de Ciências Farmacêuticas Universidade Estadual Paulista (UNESP)
dc.format.extent1048-1054
dc.identifierhttp://dx.doi.org/10.5935/0103-5053.20150362
dc.identifier.citationJournal of the Brazilian Chemical Society, v. 27, n. 6, p. 1048-1054, 2016.
dc.identifier.doi10.5935/0103-5053.20150362
dc.identifier.fileS0103-50532016000601048.pdf
dc.identifier.issn1678-4790
dc.identifier.issn0103-5053
dc.identifier.scieloS0103-50532016000601048
dc.identifier.scopus2-s2.0-84973360980
dc.identifier.urihttp://hdl.handle.net/11449/173048
dc.language.isoeng
dc.relation.ispartofJournal of the Brazilian Chemical Society
dc.relation.ispartofsjr0,357
dc.relation.ispartofsjr0,357
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAnthostomella brabeji
dc.subjectAntimicrobial activity
dc.subjectEndophytic fungus
dc.subjectPaepalanthus planifolius
dc.titleCompounds of Anthostomella brabeji, an endophytic fungus isolated from Paepalanthus planifolius (Eriocaulaceae)en
dc.typeArtigo
unesp.author.lattes0037579054083160[3]
unesp.author.orcid0000-0001-7616-9652[3]

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